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package Statistics::LogRank; |
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$VERSION = '0.03'; |
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22636
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use strict; |
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use Carp; |
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99
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933
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use Statistics::Distributions; |
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3674
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480
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############## |
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sub new |
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{ |
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my $proto = shift; |
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my $class = ref($proto) || $proto; |
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my $self= {}; |
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bless($self,$class); |
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return $self; |
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} |
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############## |
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############## |
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sub load_data { |
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my $self = shift; |
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my $sample_name = shift; |
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my (@sample_data)=@_; |
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$self->{sample_data}->{$sample_name}=\@sample_data; |
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return $self; |
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} # end sub load_data |
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############## |
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############## |
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sub perform_log_rank_test { |
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my $self=shift; |
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my ($first_survive_name,$first_fail_name,$second_survive_name,$second_fail_name)=@_; |
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my (@e,@d,@v); |
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my ($N1,$D,$N2,$N); |
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my $count=0; |
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while ($count < @{$self->{sample_data}->{$first_survive_name}}) |
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{ |
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$N1 = ${$self->{sample_data}->{$first_survive_name}}[$count]; |
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$D = ${$self->{sample_data}->{$first_fail_name}}[$count] + ${$self->{sample_data}->{$second_fail_name}}[$count]; |
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$N2 = ${$self->{sample_data}->{$second_survive_name}}[$count]; |
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$N = $N1 + $N2; |
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if ($N1 + $N2 == 0) {$e[$count]=0;} |
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else {$e[$count] = $N1 * $D / ( $N1 + $N2);} |
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$d[$count] = ${$self->{sample_data}->{$first_fail_name}}[$count] - $e[$count]; |
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if (($N**2 * ($N-1))==0) {$v[$count]=0;} |
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0
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else {$v[$count] = ($N1 * $N2 * $D *($N - $D)) / ($N**2 * ($N-1));} |
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$count++; |
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} # end while |
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1
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my $total_e=0; |
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my $total_d=0; |
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my $total_v=0; |
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1
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9
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my $count=0; |
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while ($count < @{$self->{sample_data}->{$first_survive_name}}) |
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30
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{ |
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$total_e += $e[$count]; |
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$total_d += $d[$count]; |
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$total_v += $v[$count]; |
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$count++ |
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} |
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1
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if ($total_v ==0) {$total_v = 0.000000000001;} |
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0
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1
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my $log_rank_statistic = $total_d**2 / $total_v; |
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1
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7
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my $chi_prob=Statistics::Distributions::chisqrprob (1,$log_rank_statistic); |
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1
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return ($log_rank_statistic,$chi_prob); |
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} # end sub perform_log_rank_test |
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############## |
85
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1; |
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87
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__END__ |