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# bioperl module for Bio::Variation::SNP |
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# |
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# Copyright Allen Day , Stan Nelson |
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# Human Genetics, UCLA Medical School, University of California, Los Angeles |
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=head1 NAME |
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Bio::Variation::SNP - submitted SNP |
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=head1 SYNOPSIS |
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$SNP = Bio::Variation::SNP->new (); |
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=head1 DESCRIPTION |
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Inherits from Bio::Variation::SeqDiff and Bio::Variation::Allele, with |
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additional methods that are (db)SNP specific (ie, refSNP/subSNP IDs, batch |
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IDs, validation methods). |
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=head1 FEEDBACK |
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=head2 Mailing Lists |
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User feedback is an integral part of the evolution of this and other |
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Bioperl modules. Send your comments and suggestions preferably to one |
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of the Bioperl mailing lists. Your participation is much appreciated. |
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bioperl-l@bioperl.org - General discussion |
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http://bioperl.org/wiki/Mailing_lists - About the mailing lists |
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=head2 Support |
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Please direct usage questions or support issues to the mailing list: |
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I |
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rather than to the module maintainer directly. Many experienced and |
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reponsive experts will be able look at the problem and quickly |
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address it. Please include a thorough description of the problem |
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with code and data examples if at all possible. |
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=head2 Reporting Bugs |
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Report bugs to the Bioperl bug tracking system to help us keep track |
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the bugs and their resolution. Bug reports can be submitted via the |
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web: |
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https://github.com/bioperl/bioperl-live/issues |
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=head1 AUTHOR |
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Allen Day Eallenday@ucla.eduE |
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=head1 APPENDIX |
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The rest of the documentation details each of the object |
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methods. Internal methods are usually preceded with a _ |
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=cut |
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# Let the code begin... |
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package Bio::Variation::SNP; |
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use strict; |
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66
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use vars qw($AUTOLOAD); |
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use Bio::Root::Root; |
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use base qw(Bio::Variation::SeqDiff Bio::Variation::Allele); |
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=head2 get/set-able methods |
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Usage : $is = $snp->method() |
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Function: for getting/setting attributes |
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Returns : a value. probably a scalar. |
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Args : if you're trying to set an attribute, pass in the new value. |
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Methods: |
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-------- |
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id |
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type |
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observed |
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seq_5 |
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seq_3 |
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ncbi_build |
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ncbi_chr_hits |
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ncbi_ctg_hits |
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ncbi_seq_loc |
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ucsc_build |
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ucsc_chr_hits |
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ucsc_ctg_hits |
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heterozygous |
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heterozygous_SE |
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validated |
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genotype |
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handle |
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batch_id |
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method |
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locus_id |
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symbol |
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mrna |
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protein |
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functional_class |
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=cut |
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#' |
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my %OK_AUTOLOAD = ( |
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id => '', |
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type => '', |
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observed => [], |
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seq_5 => '', |
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seq_3 => '', |
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ncbi_build => '', |
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ncbi_chr_hits => '', |
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ncbi_ctg_hits => '', |
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ncbi_seq_loc => '', |
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ucsc_build => '', |
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ucsc_chr_hits => '', |
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ucsc_ctg_hits => '', |
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heterozygous => '', |
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heterozygous_SE => '', |
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validated => '', |
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genotype => '', |
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handle => '', |
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batch_id => '', |
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method => '', |
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locus_id => '', |
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symbol => '', |
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mrna => '', |
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protein => '', |
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functional_class => '', |
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); |
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sub AUTOLOAD { |
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my $self = shift; |
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my $param = $AUTOLOAD; |
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$param =~ s/.*:://; |
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$self->throw(__PACKAGE__." doesn't implement $param") unless defined $OK_AUTOLOAD{$param}; |
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if( ref $OK_AUTOLOAD{$param} eq 'ARRAY' ) { |
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push @{$self->{$param}}, shift if @_; |
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return $self->{$param}->[scalar(@{$self->{$param}}) - 1]; |
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} else { |
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$self->{$param} = shift if @_; |
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return $self->{$param}; |
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} |
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} |
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#foreach my $slot (keys %RWSLOT){ |
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# no strict "refs"; #add class methods to package |
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# *$slot = sub { |
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# shift; |
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# $RWSLOT{$slot} = shift if @_; |
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# return $RWSLOT{$slot}; |
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# }; |
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#} |
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161
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=head2 is_subsnp |
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Title : is_subsnp |
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Usage : $is = $snp->is_subsnp() |
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Function: returns 1 if $snp is a subSNP |
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Returns : 1 or undef |
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Args : NONE |
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=cut |
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sub is_subsnp { |
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return shift->{is_subsnp}; |
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} |
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=head2 subsnp |
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Title : subsnp |
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Usage : $subsnp = $snp->subsnp() |
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Function: returns the currently active subSNP of $snp |
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Returns : Bio::Variation::SNP |
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Args : NONE |
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183
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=cut |
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sub subsnp { |
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my $self = shift; |
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return $self->{subsnps}->[ scalar($self->each_subsnp) - 1 ]; |
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} |
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=head2 add_subsnp |
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192
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Title : add_subsnp |
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Usage : $subsnp = $snp->add_subsnp() |
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Function: pushes the previous value returned by subsnp() onto a stack, |
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accessible with each_subsnp(). |
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Sets return value of subsnp() to a new Bio::Variation::SNP |
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object, and returns that object. |
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Returns : Bio::Varitiation::SNP |
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Args : NONE |
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201
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=cut |
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203
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sub add_subsnp { |
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1
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my $self = shift; |
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$self->throw("add_subsnp(): cannot add subSNP to subSNP, only to refSNP") |
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if $self->is_subsnp; |
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208
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my $subsnp = Bio::Variation::SNP->new; |
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push @{$self->{subsnps}}, $subsnp; |
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$self->subsnp->{is_subsnp} = 1; |
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return $self->subsnp; |
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} |
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214
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=head2 each_subsnp |
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215
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216
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Title : each_subsnp |
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217
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Usage : @subsnps = $snp->each_subsnp() |
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218
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Function: returns a list of the subSNPs of a refSNP |
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219
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Returns : list |
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220
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Args : NONE |
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221
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222
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=cut |
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223
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224
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sub each_subsnp { |
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225
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36
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36
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1
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38
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my $self = shift; |
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226
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36
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50
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48
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$self->throw("each_subsnp(): cannot be called on a subSNP") |
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227
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if $self->is_subsnp; |
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228
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36
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41
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return @{$self->{subsnps}}; |
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36
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163
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229
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} |
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230
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231
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1; |