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# |
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# BioPerl module for Bio::Ontology::GOterm |
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# |
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# Please direct questions and support issues to |
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# |
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# Cared for by Christian M. Zmasek or |
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# |
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# (c) Christian M. Zmasek, czmasek-at-burnham.org, 2002. |
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# (c) GNF, Genomics Institute of the Novartis Research Foundation, 2002. |
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# |
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# You may distribute this module under the same terms as perl itself. |
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# Refer to the Perl Artistic License (see the license accompanying this |
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# software package, or see http://www.perl.com/language/misc/Artistic.html) |
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# for the terms under which you may use, modify, and redistribute this module. |
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# |
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# THIS PACKAGE IS PROVIDED "AS IS" AND WITHOUT ANY EXPRESS OR IMPLIED |
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# WARRANTIES, INCLUDING, WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF |
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# MERCHANTIBILITY AND FITNESS FOR A PARTICULAR PURPOSE. |
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# |
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# You may distribute this module under the same terms as perl itself |
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# POD documentation - main docs before the code |
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=head1 NAME |
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Bio::Ontology::GOterm - representation of GO terms |
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=head1 SYNOPSIS |
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$term = Bio::Ontology::GOterm->new |
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( -go_id => "GO:0016847", |
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-name => "1-aminocyclopropane-1-carboxylate synthase", |
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-definition => "Catalysis of ...", |
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-is_obsolete => 0, |
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-comment => "" ); |
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$term->add_definition_references( @refs ); |
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$term->add_secondary_GO_ids( @ids ); |
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$term->add_aliases( @aliases ); |
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foreach my $dr ( $term->each_definition_reference() ) { |
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print $dr, "\n"; |
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} |
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# etc. |
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=head1 DESCRIPTION |
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This is "dumb" class for GO terms (it provides no functionality |
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related to graphs). Implements Bio::Ontology::TermI. |
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=head1 FEEDBACK |
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=head2 Mailing Lists |
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User feedback is an integral part of the evolution of this and other |
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Bioperl modules. Send your comments and suggestions preferably to one |
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of the Bioperl mailing lists. Your participation is much appreciated. |
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bioperl-l@bioperl.org - General discussion |
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http://bioperl.org/wiki/Mailing_lists - About the mailing lists |
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=head2 Support |
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Please direct usage questions or support issues to the mailing list: |
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I |
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rather than to the module maintainer directly. Many experienced and |
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reponsive experts will be able look at the problem and quickly |
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address it. Please include a thorough description of the problem |
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with code and data examples if at all possible. |
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=head2 Reporting Bugs |
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Report bugs to the Bioperl bug tracking system to help us keep track |
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the bugs and their resolution. Bug reports can be submitted via the web: |
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https://github.com/bioperl/bioperl-live/issues |
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=head1 AUTHOR |
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Christian M. Zmasek |
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Email: czmasek-at-burnham.org or cmzmasek@yahoo.com |
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WWW: http://monochrome-effect.net/ |
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Address: |
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Genomics Institute of the Novartis Research Foundation |
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10675 John Jay Hopkins Drive |
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San Diego, CA 92121 |
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=head1 APPENDIX |
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The rest of the documentation details each of the object |
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methods. |
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=cut |
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103
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104
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# Let the code begin... |
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106
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package Bio::Ontology::GOterm; |
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use strict; |
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use constant GOID_DEFAULT => "GO:0000000"; |
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use constant TRUE => 1; |
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use constant FALSE => 0; |
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use base qw(Bio::Ontology::Term); |
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=head2 new |
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Title : new |
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Usage : $term = Bio::Ontology::GOterm->new( |
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-go_id => "GO:0016847", |
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-name => "1-aminocyclopropane-1-carboxylate synthase", |
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-definition => "Catalysis of ...", |
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-is_obsolete => 0, |
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-comment => "" ); |
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Function: Creates a new Bio::Ontology::GOterm. |
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Returns : A new Bio::Ontology::GOterm object. |
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Args : -go_id => the goid of this GO term [GO:nnnnnnn] |
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or [nnnnnnn] (nnnnnnn is a zero-padded |
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integer of seven digits) |
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-name => the name of this GO term [scalar] |
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-definition => the definition of this GO term [scalar] |
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-ontology => the ontology for this term (a |
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Bio::Ontology::OntologyI compliant object) |
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-version => version information [scalar] |
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-is_obsolete => the obsoleteness of this GO term [0 or 1] |
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-comment => a comment [scalar] |
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=cut |
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139
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sub new { |
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my( $class,@args ) = @_; |
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my $self = $class->SUPER::new( @args ); |
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my ( $GO_id ) |
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= $self->_rearrange( [ qw( GO_ID ) ], @args ); |
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$GO_id && $self->GO_id( $GO_id ); |
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return $self; |
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153
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} # new |
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=head2 init |
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Title : init() |
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Usage : $term->init(); |
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Function: Initializes this GOterm to all "" and empty lists. |
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Returns : |
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Args : |
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164
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=cut |
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sub init { |
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168
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1
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my $self = shift; |
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170
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# first call the inherited version to properly chain up the hierarchy |
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235
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$self->SUPER::init(@_); |
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# then only initialize what we implement ourselves here |
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#$self->GO_id( GOID_DEFAULT ); |
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} # init |
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179
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=head2 GO_id |
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Title : GO_id |
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Usage : $term->GO_id( "GO:0003947" ); |
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or |
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184
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print $term->GO_id(); |
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185
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Function: Set/get for the goid of this GO term. |
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187
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This is essentially an alias to identifier(), with added |
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format checking. |
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189
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190
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Returns : The goid [GO:nnnnnnn]. |
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191
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Args : The goid [GO:nnnnnnn] or [nnnnnnn] (nnnnnnn is a |
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192
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zero-padded integer of seven digits) (optional). |
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193
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194
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=cut |
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195
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196
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sub GO_id { |
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197
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169
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169
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1
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3568
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my $self = shift; |
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198
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169
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110
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my $value; |
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199
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200
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169
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229
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if ( @_ ) { |
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201
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3
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11
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$value = $self->_check_go_id( shift ); |
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202
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3
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7
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unshift(@_, $value); |
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203
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} |
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204
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205
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169
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233
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return $self->identifier( @_ ); |
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206
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207
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} # GO_id |
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208
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209
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210
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=head2 get_secondary_GO_ids |
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211
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212
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Title : get_secondary_GO_ids |
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213
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Usage : @ids = $term->get_secondary_GO_ids(); |
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214
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Function: Returns a list of secondary goids of this Term. |
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215
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216
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This is aliased to remove_secondary_ids(). |
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217
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218
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Returns : A list of secondary goids [array of [GO:nnnnnnn]] |
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(nnnnnnn is a zero-padded integer of seven digits). |
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Args : |
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222
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=cut |
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223
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224
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sub get_secondary_GO_ids { |
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225
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7
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7
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1
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1640
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return shift->get_secondary_ids(@_); |
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226
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} # get_secondary_GO_ids |
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227
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228
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229
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=head2 add_secondary_GO_id |
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230
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231
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Title : add_secondary_GO_id |
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232
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Usage : $term->add_secondary_GO_id( @ids ); |
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233
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or |
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234
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$term->add_secondary_GO_id( $id ); |
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235
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Function: Pushes one or more secondary goids into |
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236
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the list of secondary goids. |
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237
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238
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This is aliased to remove_secondary_ids(). |
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239
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240
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Returns : |
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241
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Args : One secondary goid [GO:nnnnnnn or nnnnnnn] or a list |
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242
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of secondary goids [array of [GO:nnnnnnn or nnnnnnn]] |
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243
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(nnnnnnn is a zero-padded integer of seven digits). |
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244
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245
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=cut |
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246
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247
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sub add_secondary_GO_id { |
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248
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2
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2
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1
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10
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return shift->add_secondary_id(@_); |
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249
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} # add_secondary_GO_id |
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250
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251
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252
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=head2 remove_secondary_GO_ids |
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253
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254
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Title : remove_secondary_GO_ids() |
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255
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Usage : $term->remove_secondary_GO_ids(); |
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256
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Function: Deletes (and returns) the secondary goids of this Term. |
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257
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258
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This is aliased to remove_secondary_ids(). |
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259
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260
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Returns : A list of secondary goids [array of [GO:nnnnnnn]] |
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261
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(nnnnnnn is a zero-padded integer of seven digits). |
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262
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Args : |
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263
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264
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=cut |
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265
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266
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sub remove_secondary_GO_ids { |
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267
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2
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2
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1
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8
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return shift->remove_secondary_ids(@_); |
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268
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} # remove_secondary_GO_ids |
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269
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270
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271
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=head2 to_string |
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272
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273
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Title : to_string() |
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274
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Usage : print $term->to_string(); |
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275
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Function: to_string method for GO terms. |
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276
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Returns : A string representation of this GOterm. |
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277
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Args : |
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278
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279
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=cut |
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280
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281
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sub to_string { |
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282
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1
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1
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1
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4
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my( $self ) = @_; |
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283
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284
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1
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2
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my $s = ""; |
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285
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286
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1
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2
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$s .= "-- GO id:\n"; |
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287
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1
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50
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3
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$s .= ($self->GO_id() || '')."\n"; |
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288
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1
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2
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$s .= "-- Name:\n"; |
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289
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1
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50
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3
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$s .= ($self->name() || '') ."\n"; |
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290
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1
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1
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$s .= "-- Definition:\n"; |
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291
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1
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50
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2
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$s .= ($self->definition() || '') ."\n"; |
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292
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1
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1
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$s .= "-- Category:\n"; |
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293
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1
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50
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2
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if ( defined( $self->ontology() ) ) { |
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294
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0
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0
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$s .= $self->ontology()->name()."\n"; |
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295
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} |
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296
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else { |
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297
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1
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1
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$s .= "\n"; |
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298
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} |
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299
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1
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2
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$s .= "-- Version:\n"; |
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300
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1
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50
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4
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$s .= ($self->version() || '') ."\n"; |
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301
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1
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2
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$s .= "-- Is obsolete:\n"; |
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302
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1
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2
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$s .= $self->is_obsolete()."\n"; |
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303
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1
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1
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$s .= "-- Comment:\n"; |
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304
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1
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50
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2
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$s .= ($self->comment() || '') ."\n"; |
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305
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1
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1
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$s .= "-- Definition references:\n"; |
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306
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1
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2
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$s .= $self->_array_to_string( $self->get_dbxrefs() )."\n"; |
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307
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1
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2
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$s .= "-- Secondary GO ids:\n"; |
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308
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1
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11
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$s .= $self->_array_to_string( $self->get_secondary_GO_ids() )."\n"; |
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309
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1
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1
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$s .= "-- Aliases:\n"; |
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310
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1
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3
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$s .= $self->_array_to_string( $self->get_synonyms() ); |
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311
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312
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1
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7
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return $s; |
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313
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314
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} # to_string |
|
315
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316
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317
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318
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319
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# Title : _check_go_id |
|
320
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# Function: Checks whether the argument is [GO:nnnnnnn]. |
|
321
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# If "GO:" is not present, it adds it. |
|
322
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# Returns : The canonical GO id. |
|
323
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# Args : The value to be checked. |
|
324
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|
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sub _check_go_id { |
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325
|
3
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3
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5
|
my ( $self, $value ) = @_; |
|
326
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3
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50
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33
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22
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unless ( $value =~ /^(GO:)?\d{7}$/ || $value eq GOID_DEFAULT ) { |
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327
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0
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0
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$self->throw( "Found [" . $value |
|
328
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. "] where [GO:nnnnnnn] or [nnnnnnn] expected" ); |
|
329
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|
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} |
|
330
|
3
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100
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10
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unless ( $value =~ /^GO:/ ) { |
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331
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1
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3
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$value = "GO:".$value; |
|
332
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|
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} |
|
333
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3
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4
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return $value; |
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334
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} # _check_go_id |
|
335
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336
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337
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338
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# Title : _array_to_string |
|
339
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|
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# Function: |
|
340
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# Returns : |
|
341
|
|
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|
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# Args : |
|
342
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|
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sub _array_to_string { |
|
343
|
3
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3
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4
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my( $self, @value ) = @_; |
|
344
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345
|
3
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3
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my $s = ""; |
|
346
|
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|
347
|
3
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|
7
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for ( my $i = 0; $i < scalar( @value ); ++$i ) { |
|
348
|
0
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0
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0
|
if ( ! ref( $value[ $i ] ) ) { |
|
349
|
0
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0
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$s .= "#" . $i . "\n-- " . $value[ $i ] . "\n"; |
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350
|
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|
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} |
|
351
|
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} |
|
352
|
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353
|
3
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5
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return $s; |
|
354
|
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355
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} # _array_to_string |
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356
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|
357
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################################################################# |
|
358
|
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# aliases or forwards to maintain backward compatibility |
|
359
|
|
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################################################################# |
|
360
|
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361
|
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|
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*each_secondary_GO_id = \&get_secondary_GO_ids; |
|
362
|
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*add_secondary_GO_ids = \&add_secondary_GO_id; |
|
363
|
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|
364
|
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1; |