line |
stmt |
bran |
cond |
sub |
pod |
time |
code |
1
|
|
|
|
|
|
|
package XMS::MotifSet;
|
2
|
|
|
|
|
|
|
|
3
|
1
|
|
|
1
|
|
38135
|
use 5.008008;
|
|
1
|
|
|
|
|
5
|
|
|
1
|
|
|
|
|
44
|
|
4
|
1
|
|
|
1
|
|
5
|
use strict;
|
|
1
|
|
|
|
|
2
|
|
|
1
|
|
|
|
|
35
|
|
5
|
1
|
|
|
1
|
|
4
|
use warnings;
|
|
1
|
|
|
|
|
8
|
|
|
1
|
|
|
|
|
46
|
|
6
|
1
|
|
|
1
|
|
5
|
use Carp;
|
|
1
|
|
|
|
|
2
|
|
|
1
|
|
|
|
|
370
|
|
7
|
|
|
|
|
|
|
require Exporter;
|
8
|
|
|
|
|
|
|
|
9
|
|
|
|
|
|
|
our @ISA = qw(Exporter);
|
10
|
|
|
|
|
|
|
|
11
|
|
|
|
|
|
|
|
12
|
|
|
|
|
|
|
# This allows declaration use XMS ':all';
|
13
|
|
|
|
|
|
|
|
14
|
|
|
|
|
|
|
|
15
|
|
|
|
|
|
|
our %EXPORT_TAGS = ( 'all' => [ qw(
|
16
|
|
|
|
|
|
|
|
17
|
|
|
|
|
|
|
) ] );
|
18
|
|
|
|
|
|
|
|
19
|
|
|
|
|
|
|
our @EXPORT_OK = ( @{ $EXPORT_TAGS{'all'} } );
|
20
|
|
|
|
|
|
|
|
21
|
|
|
|
|
|
|
our @EXPORT = qw(
|
22
|
|
|
|
|
|
|
|
23
|
|
|
|
|
|
|
);
|
24
|
|
|
|
|
|
|
|
25
|
|
|
|
|
|
|
our $VERSION = '0.01';
|
26
|
|
|
|
|
|
|
|
27
|
1
|
|
|
1
|
|
737
|
use XML::Writer;
|
|
0
|
|
|
|
|
|
|
|
0
|
|
|
|
|
|
|
28
|
|
|
|
|
|
|
use XML::Writer::String;
|
29
|
|
|
|
|
|
|
use IO::File;
|
30
|
|
|
|
|
|
|
use XMS::WeightMatrix;
|
31
|
|
|
|
|
|
|
use XMS::Motif;
|
32
|
|
|
|
|
|
|
use XML::DOM;
|
33
|
|
|
|
|
|
|
|
34
|
|
|
|
|
|
|
|
35
|
|
|
|
|
|
|
|
36
|
|
|
|
|
|
|
sub new {
|
37
|
|
|
|
|
|
|
|
38
|
|
|
|
|
|
|
my $class = shift;
|
39
|
|
|
|
|
|
|
my $self = {};
|
40
|
|
|
|
|
|
|
my(@motifs) = @_;
|
41
|
|
|
|
|
|
|
my ($temp) = @motifs;
|
42
|
|
|
|
|
|
|
|
43
|
|
|
|
|
|
|
if(ref($temp) eq "XMS::Motif"){
|
44
|
|
|
|
|
|
|
@{$self->{motifs}} = @motifs;
|
45
|
|
|
|
|
|
|
|
46
|
|
|
|
|
|
|
}else{
|
47
|
|
|
|
|
|
|
|
48
|
|
|
|
|
|
|
my $parser = new XML::DOM::Parser;
|
49
|
|
|
|
|
|
|
my $doc = $parser->parsefile($temp);
|
50
|
|
|
|
|
|
|
my $root = $doc->getDocumentElement();
|
51
|
|
|
|
|
|
|
|
52
|
|
|
|
|
|
|
my @motifnodes = $root->getElementsByTagName("motif");
|
53
|
|
|
|
|
|
|
|
54
|
|
|
|
|
|
|
if (scalar @motifnodes == 0){
|
55
|
|
|
|
|
|
|
die "Corrupt input XMS file";
|
56
|
|
|
|
|
|
|
}
|
57
|
|
|
|
|
|
|
|
58
|
|
|
|
|
|
|
my $m=0;
|
59
|
|
|
|
|
|
|
my @motifarray=();
|
60
|
|
|
|
|
|
|
|
61
|
|
|
|
|
|
|
foreach my $motif (@motifnodes){
|
62
|
|
|
|
|
|
|
|
63
|
|
|
|
|
|
|
|
64
|
|
|
|
|
|
|
my $motifname = $motif->getElementsByTagName("name")->item(0)->getFirstChild()->getData;
|
65
|
|
|
|
|
|
|
|
66
|
|
|
|
|
|
|
my $threshold = $motif->getElementsByTagName("threshold")->item(0)->getFirstChild->getData;
|
67
|
|
|
|
|
|
|
|
68
|
|
|
|
|
|
|
my @props = $motif->getElementsByTagName("prop");
|
69
|
|
|
|
|
|
|
|
70
|
|
|
|
|
|
|
####### Begin reading annotation key value pairs ##########
|
71
|
|
|
|
|
|
|
|
72
|
|
|
|
|
|
|
my %annotations;
|
73
|
|
|
|
|
|
|
foreach my $prop (@props){
|
74
|
|
|
|
|
|
|
my ($keynode) = $prop->getElementsByTagName("key");
|
75
|
|
|
|
|
|
|
my $key="";
|
76
|
|
|
|
|
|
|
if ( $keynode->getFirstChild() ) {
|
77
|
|
|
|
|
|
|
$key = $keynode->getFirstChild()->getData;
|
78
|
|
|
|
|
|
|
}
|
79
|
|
|
|
|
|
|
my ($valuenode) = $prop->getElementsByTagName("value");
|
80
|
|
|
|
|
|
|
my $value="";
|
81
|
|
|
|
|
|
|
if ( $valuenode->getFirstChild() ) {
|
82
|
|
|
|
|
|
|
$value = $valuenode->getFirstChild()->getData;
|
83
|
|
|
|
|
|
|
}
|
84
|
|
|
|
|
|
|
if ( $key ne "" ){
|
85
|
|
|
|
|
|
|
$annotations{$key} = $value;
|
86
|
|
|
|
|
|
|
}
|
87
|
|
|
|
|
|
|
}
|
88
|
|
|
|
|
|
|
|
89
|
|
|
|
|
|
|
####### End reading annotation key value pairs ##########
|
90
|
|
|
|
|
|
|
|
91
|
|
|
|
|
|
|
my @wmnodes = $motif->getElementsByTagName("weightmatrix");
|
92
|
|
|
|
|
|
|
my @columnsarray=();
|
93
|
|
|
|
|
|
|
foreach my $wmnode (@wmnodes) {
|
94
|
|
|
|
|
|
|
|
95
|
|
|
|
|
|
|
my @columns=$motif->getElementsByTagName("column");
|
96
|
|
|
|
|
|
|
|
97
|
|
|
|
|
|
|
my %columnhash;
|
98
|
|
|
|
|
|
|
foreach my $column (@columns){
|
99
|
|
|
|
|
|
|
|
100
|
|
|
|
|
|
|
my @weights=$column->getElementsByTagName("weight");
|
101
|
|
|
|
|
|
|
|
102
|
|
|
|
|
|
|
foreach my $weight (@weights){
|
103
|
|
|
|
|
|
|
|
104
|
|
|
|
|
|
|
my $weightsymbol = $weight->getAttributeNode("symbol");
|
105
|
|
|
|
|
|
|
my $symbolvalue = $weightsymbol->getValue;
|
106
|
|
|
|
|
|
|
|
107
|
|
|
|
|
|
|
my $weightvalue=$weight->getFirstChild->getData;
|
108
|
|
|
|
|
|
|
|
109
|
|
|
|
|
|
|
$columnhash{$symbolvalue} = $weightvalue;
|
110
|
|
|
|
|
|
|
}
|
111
|
|
|
|
|
|
|
my $count=0;
|
112
|
|
|
|
|
|
|
my @wmvalues=();
|
113
|
|
|
|
|
|
|
foreach my $key (sort keys %columnhash){
|
114
|
|
|
|
|
|
|
$wmvalues[$count]=$columnhash{$key};
|
115
|
|
|
|
|
|
|
$count++;
|
116
|
|
|
|
|
|
|
}
|
117
|
|
|
|
|
|
|
push(@columnsarray,[@wmvalues]);
|
118
|
|
|
|
|
|
|
}
|
119
|
|
|
|
|
|
|
}
|
120
|
|
|
|
|
|
|
|
121
|
|
|
|
|
|
|
my $wmobj = XMS::WeightMatrix->new(@columnsarray);
|
122
|
|
|
|
|
|
|
my $motifobj = XMS::Motif->new($wmobj,$motifname,$threshold,%annotations);
|
123
|
|
|
|
|
|
|
$motifarray[$m] = $motifobj;
|
124
|
|
|
|
|
|
|
$m++;
|
125
|
|
|
|
|
|
|
}
|
126
|
|
|
|
|
|
|
@{$self->{motifs}} = @motifarray;
|
127
|
|
|
|
|
|
|
}
|
128
|
|
|
|
|
|
|
|
129
|
|
|
|
|
|
|
$self->{output} = XML::Writer::String->new();
|
130
|
|
|
|
|
|
|
$self->{writer} = new XML::Writer(OUTPUT => $self->{output}, DATA_MODE => 'TRUE', DATA_INDENT=>3);
|
131
|
|
|
|
|
|
|
|
132
|
|
|
|
|
|
|
bless($self,$class);
|
133
|
|
|
|
|
|
|
return $self;
|
134
|
|
|
|
|
|
|
|
135
|
|
|
|
|
|
|
}
|
136
|
|
|
|
|
|
|
|
137
|
|
|
|
|
|
|
|
138
|
|
|
|
|
|
|
sub toXML {
|
139
|
|
|
|
|
|
|
|
140
|
|
|
|
|
|
|
my $self = shift;
|
141
|
|
|
|
|
|
|
my $writer = $self->{writer};
|
142
|
|
|
|
|
|
|
my $output = $self->{output};
|
143
|
|
|
|
|
|
|
|
144
|
|
|
|
|
|
|
my @motifs = @{$self->{motifs}};
|
145
|
|
|
|
|
|
|
|
146
|
|
|
|
|
|
|
|
147
|
|
|
|
|
|
|
$writer->startTag("motifset");
|
148
|
|
|
|
|
|
|
for(my $m=0;$m<@motifs;$m++){
|
149
|
|
|
|
|
|
|
$self->{motifs}[$m]->toXML($writer);
|
150
|
|
|
|
|
|
|
}
|
151
|
|
|
|
|
|
|
|
152
|
|
|
|
|
|
|
$writer->endTag("motifset");
|
153
|
|
|
|
|
|
|
|
154
|
|
|
|
|
|
|
$writer->end();
|
155
|
|
|
|
|
|
|
return $self->{output}->value();
|
156
|
|
|
|
|
|
|
}
|
157
|
|
|
|
|
|
|
|
158
|
|
|
|
|
|
|
|
159
|
|
|
|
|
|
|
sub toString {
|
160
|
|
|
|
|
|
|
|
161
|
|
|
|
|
|
|
my $self = shift;
|
162
|
|
|
|
|
|
|
my @motifs = @{$self->{motifs}};
|
163
|
|
|
|
|
|
|
|
164
|
|
|
|
|
|
|
my $rawstring = "";
|
165
|
|
|
|
|
|
|
|
166
|
|
|
|
|
|
|
for(my $m=0;$m<@motifs;$m++){
|
167
|
|
|
|
|
|
|
$rawstring = $rawstring.$self->{motifs}[$m]->toString();
|
168
|
|
|
|
|
|
|
if ($m<(@motifs-1)){
|
169
|
|
|
|
|
|
|
$rawstring = $rawstring."\n";
|
170
|
|
|
|
|
|
|
}
|
171
|
|
|
|
|
|
|
}
|
172
|
|
|
|
|
|
|
return $rawstring;
|
173
|
|
|
|
|
|
|
}
|
174
|
|
|
|
|
|
|
|
175
|
|
|
|
|
|
|
|
176
|
|
|
|
|
|
|
1;
|
177
|
|
|
|
|
|
|
__END__
|