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# Module for Bio::PhyloNetwork::Factory |
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# |
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# Please direct questions and support issues to |
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# |
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# Cared for by Gabriel Cardona |
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# |
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# Copyright Gabriel Cardona |
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# |
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# You may distribute this module under the same terms as perl itself |
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# POD documentation - main docs before the code |
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=head1 NAME |
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Bio::PhyloNetwork::Factory - Module to sequentially generate |
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Phylogenetic Networks |
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=head1 SYNOPSIS |
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use strict; |
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use warnings; |
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use Bio::PhyloNetwork; |
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use Bio::PhyloNetwork::Factory; |
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# Will generate sequentially all the 4059 binary tree-child phylogenetic |
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# networks with 4 leaves |
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my $factory=Bio::PhyloNetwork::Factory->new(-numleaves=>4); |
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my @nets; |
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while (my $net=$factory->next_network()) { |
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push @nets,$net; |
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print "".(scalar @nets).": ".$net->eNewick()."\n"; |
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} |
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=head1 DESCRIPTION |
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Sequentially builds a (binary tree-child) phylogenetic network each time |
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next_network is called. |
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=head1 AUTHOR |
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Gabriel Cardona, gabriel(dot)cardona(at)uib(dot)es |
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=head1 SEE ALSO |
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L |
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=head1 APPENDIX |
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The rest of the documentation details each of the object methods. |
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=cut |
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package Bio::PhyloNetwork::Factory; |
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use strict; |
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use warnings; |
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use base qw(Bio::Root::Root); |
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use Bio::PhyloNetwork; |
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use Bio::PhyloNetwork::TreeFactory; |
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555
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=head2 new |
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Title : new |
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Usage : my $factory = new Bio::PhyloNetwork::Factory(); |
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Function: Creates a new Bio::PhyloNetwork::Factory |
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Returns : Bio::PhyloNetwork::RandomFactory |
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Args : -numleaves => integer |
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OR |
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-leaves => reference to an array (of leaves names) |
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-numhybrids => integer [default = numleaves -1] |
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-recurse => boolean [optional] |
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80
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Returns a Bio::PhyloNetwork::Factory object. Such an object will |
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sequentially create binary tree-child phylogenetic networks |
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each time next_network is called. |
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If the parameter -leaves=E\@leaves is given, then the set of leaves of |
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these networks will be @leaves. If it is given the parameter |
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-numleaves=E$numleaves, then the set of leaves will be "l1"..."l$numleaves". |
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If the parameter -numhybrids=E$numhybrids is given, then the generated |
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networks will have at most $numhybrids hybrid nodes. Note that, necessarily, |
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$numhybrids E $numleaves. |
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If the parameter -recurse=E1 is given, then all networks with number of hybrid |
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nodes less or equal to $numhybrids will be given; otherwise only those with |
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exactly $numhybrids hybrid nodes. |
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96
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=cut |
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98
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sub new { |
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2
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2
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1
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139
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my ($pkg,@args)=@_; |
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101
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2
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13
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my $self=$pkg->SUPER::new(@args); |
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103
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2
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10
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my ($leavesR,$numleaves,$numhybrids,$recurse)= |
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$self->_rearrange([qw(LEAVES |
105
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NUMLEAVES |
106
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NUMHYBRIDS |
107
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RECURSE)],@args); |
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2
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3
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my @leaves; |
109
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2
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100
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66
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7
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if ((! defined $leavesR) && (defined $numleaves)) { |
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1
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3
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@leaves=map {"l$_"} (1..$numleaves); |
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111
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1
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3
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$leavesR=\@leaves; |
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} |
113
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2
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50
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4
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if (! defined $leavesR) { |
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0
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0
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$self->throw("No leaves set neither numleaves given"); |
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} |
116
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2
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5
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@leaves=@$leavesR; |
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2
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3
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$self->{leaves}=$leavesR; |
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2
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2
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$numleaves=@leaves; |
119
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2
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3
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$self->{numleaves}=$numleaves; |
120
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121
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2
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100
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6
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$recurse ||= 0; |
122
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2
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100
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3
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if (! defined $numhybrids) { |
123
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1
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2
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$numhybrids=$numleaves-1; |
124
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1
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2
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$recurse=1; |
125
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} |
126
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2
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3
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$self->{recurse}=$recurse; |
127
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2
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2
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$self->{numhybrids}=$numhybrids; |
128
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2
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50
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37
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if ($numhybrids ==0) { |
129
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0
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0
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return Bio::PhyloNetwork::TreeFactory->new(-leaves=>\@leaves); |
130
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} |
131
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2
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2
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my $parent; |
132
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2
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100
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5
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if ($numhybrids > 1) { |
133
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1
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6
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$parent=new($pkg,'-leaves'=>\@leaves, |
134
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'-numhybrids'=>($numhybrids-1), |
135
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'-recurse'=>($recurse)); |
136
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} |
137
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else { |
138
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1
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25
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$parent=Bio::PhyloNetwork::TreeFactory->new(-leaves=>\@leaves); |
139
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} |
140
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2
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3
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$self->{parent}=$parent; |
141
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2
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4
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my $oldnet=$parent->next_network(); |
142
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2
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4
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$self->{oldnet}=$oldnet; |
143
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2
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4
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$self->update(); |
144
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2
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3
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$self->{found}=[]; |
145
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2
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6
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bless($self,$pkg); |
146
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} |
147
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148
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sub update { |
149
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27
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27
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0
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46
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my ($self)=@_; |
150
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151
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27
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92
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my @candidates=$self->{oldnet}->edges(); |
152
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27
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3829
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$self->{candidates}=\@candidates; |
153
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27
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52
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$self->{numcandidates}=(scalar @candidates); |
154
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27
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56
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$self->{index1}=-$self->{recurse}; |
155
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27
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53
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$self->{index2}=0; |
156
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} |
157
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158
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=head2 next_network |
159
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160
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Title : next_network |
161
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Usage : my $net=$factory->next_network() |
162
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Function: returns a network |
163
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Returns : Bio::PhyloNetwork |
164
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Args : none |
165
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166
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=cut |
167
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168
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sub next_network { |
169
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92
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92
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1
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1020
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my ($self)=@_; |
170
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92
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133
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my $numleaves=$self->{numleaves}; |
171
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92
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127
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my $numhybrids=$self->{numhybrids}; |
172
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START: |
173
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1134
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100
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2148
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if ($self->{index1}==-1) { |
174
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27
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46
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$self->{index1}++; |
175
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27
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117
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return $self->{oldnet}; |
176
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} |
177
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1107
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100
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1936
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if ($self->{index1} >= $self->{numcandidates}) { |
178
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162
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209
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$self->{index2}++; |
179
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162
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228
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$self->{index1}=0; |
180
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} |
181
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1107
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100
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1724
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if ($self->{index2} >= $self->{numcandidates}) { |
182
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27
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78
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my $oldnet=$self->{parent}->next_network(); |
183
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27
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100
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101
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if (! $oldnet) { |
184
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2
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8
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return 0; |
185
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|
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} |
186
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25
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101
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$self->{oldnet}=$oldnet; |
187
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25
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85
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$self->update(); |
188
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25
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119
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goto START; |
189
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|
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} |
190
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1080
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100
|
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1897
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if ((scalar $self->{oldnet}->hybrid_nodes())< $self->{numhybrids}-1) { |
191
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3
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10
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$self->{candidates}=[]; |
192
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3
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5
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$self->{numcandidates}=0; |
193
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3
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11
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goto START; |
194
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} |
195
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1077
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|
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|
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2365
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my $u1=$self->{candidates}->[$self->{index1}]->[0]; |
196
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1077
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|
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1419
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my $v1=$self->{candidates}->[$self->{index1}]->[1]; |
197
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1077
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|
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1376
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my $u2=$self->{candidates}->[$self->{index2}]->[0]; |
198
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1077
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1462
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my $v2=$self->{candidates}->[$self->{index2}]->[1]; |
199
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1077
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1171
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my $lbl=$self->{numhybrids}; |
200
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1077
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100
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|
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2008
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if ($self->{oldnet}->is_attackable($u1,$v1,$u2,$v2)) { |
201
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156
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|
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357
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my $net=Bio::PhyloNetwork->new(-graph=>$self->{oldnet}->graph); |
202
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156
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|
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429
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$net->do_attack($u1,$v1,$u2,$v2,$lbl); |
203
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156
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|
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|
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308
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$self->{index1}++; |
204
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156
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|
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197
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my @found=@{$self->{found}}; |
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156
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715
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205
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156
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266
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foreach my $netant (@found) { |
206
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2968
|
100
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3970
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if ($net->is_mu_isomorphic($netant) ) { |
207
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93
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852
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goto START; |
208
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} |
209
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} |
210
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63
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126
|
push @found,$net; |
211
|
63
|
|
|
|
|
155
|
$self->{found}=\@found; |
212
|
63
|
|
|
|
|
228
|
return $net; |
213
|
|
|
|
|
|
|
} |
214
|
|
|
|
|
|
|
else { |
215
|
921
|
|
|
|
|
1290
|
$self->{index1}++; |
216
|
921
|
|
|
|
|
4038
|
goto START; |
217
|
|
|
|
|
|
|
} |
218
|
|
|
|
|
|
|
} |
219
|
|
|
|
|
|
|
|
220
|
|
|
|
|
|
|
1; |