line |
stmt |
bran |
cond |
sub |
pod |
time |
code |
1
|
|
|
|
|
|
|
# |
2
|
|
|
|
|
|
|
# BioPerl module for Bio::Ontology::SimpleOntologyEngine |
3
|
|
|
|
|
|
|
# |
4
|
|
|
|
|
|
|
# Please direct questions and support issues to |
5
|
|
|
|
|
|
|
# |
6
|
|
|
|
|
|
|
# Cared for by Peter Dimitrov |
7
|
|
|
|
|
|
|
# |
8
|
|
|
|
|
|
|
# Copyright Peter Dimitrov |
9
|
|
|
|
|
|
|
# (c) Peter Dimitrov, dimitrov@gnf.org, 2002. |
10
|
|
|
|
|
|
|
# (c) GNF, Genomics Institute of the Novartis Research Foundation, 2002. |
11
|
|
|
|
|
|
|
# |
12
|
|
|
|
|
|
|
# You may distribute this module under the same terms as perl itself. |
13
|
|
|
|
|
|
|
# Refer to the Perl Artistic License (see the license accompanying this |
14
|
|
|
|
|
|
|
# software package, or see http://www.perl.com/language/misc/Artistic.html) |
15
|
|
|
|
|
|
|
# for the terms under which you may use, modify, and redistribute this module. |
16
|
|
|
|
|
|
|
# |
17
|
|
|
|
|
|
|
# THIS PACKAGE IS PROVIDED "AS IS" AND WITHOUT ANY EXPRESS OR IMPLIED |
18
|
|
|
|
|
|
|
# WARRANTIES, INCLUDING, WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF |
19
|
|
|
|
|
|
|
# MERCHANTIBILITY AND FITNESS FOR A PARTICULAR PURPOSE. |
20
|
|
|
|
|
|
|
# |
21
|
|
|
|
|
|
|
# POD documentation - main docs before the code |
22
|
|
|
|
|
|
|
|
23
|
|
|
|
|
|
|
=head1 NAME |
24
|
|
|
|
|
|
|
|
25
|
|
|
|
|
|
|
Bio::Ontology::SimpleOntologyEngine - Implementation of OntologyEngineI interface |
26
|
|
|
|
|
|
|
|
27
|
|
|
|
|
|
|
=head1 SYNOPSIS |
28
|
|
|
|
|
|
|
|
29
|
|
|
|
|
|
|
my $soe = Bio::Ontology::SimpleOntologyEngine->new; |
30
|
|
|
|
|
|
|
|
31
|
|
|
|
|
|
|
=head1 DESCRIPTION |
32
|
|
|
|
|
|
|
|
33
|
|
|
|
|
|
|
This is a "simple" implementation of Bio::Ontology::OntologyEngineI. |
34
|
|
|
|
|
|
|
|
35
|
|
|
|
|
|
|
=head1 FEEDBACK |
36
|
|
|
|
|
|
|
|
37
|
|
|
|
|
|
|
=head2 Mailing Lists |
38
|
|
|
|
|
|
|
|
39
|
|
|
|
|
|
|
User feedback is an integral part of the evolution of this and other |
40
|
|
|
|
|
|
|
Bioperl modules. Send your comments and suggestions preferably to |
41
|
|
|
|
|
|
|
the Bioperl mailing list. Your participation is much appreciated. |
42
|
|
|
|
|
|
|
|
43
|
|
|
|
|
|
|
bioperl-l@bioperl.org - General discussion |
44
|
|
|
|
|
|
|
http://bioperl.org/wiki/Mailing_lists - About the mailing lists |
45
|
|
|
|
|
|
|
|
46
|
|
|
|
|
|
|
=head2 Support |
47
|
|
|
|
|
|
|
|
48
|
|
|
|
|
|
|
Please direct usage questions or support issues to the mailing list: |
49
|
|
|
|
|
|
|
|
50
|
|
|
|
|
|
|
I |
51
|
|
|
|
|
|
|
|
52
|
|
|
|
|
|
|
rather than to the module maintainer directly. Many experienced and |
53
|
|
|
|
|
|
|
reponsive experts will be able look at the problem and quickly |
54
|
|
|
|
|
|
|
address it. Please include a thorough description of the problem |
55
|
|
|
|
|
|
|
with code and data examples if at all possible. |
56
|
|
|
|
|
|
|
|
57
|
|
|
|
|
|
|
=head2 Reporting Bugs |
58
|
|
|
|
|
|
|
|
59
|
|
|
|
|
|
|
Report bugs to the Bioperl bug tracking system to help us keep track |
60
|
|
|
|
|
|
|
of the bugs and their resolution. Bug reports can be submitted via |
61
|
|
|
|
|
|
|
the web: |
62
|
|
|
|
|
|
|
|
63
|
|
|
|
|
|
|
https://github.com/bioperl/bioperl-live/issues |
64
|
|
|
|
|
|
|
|
65
|
|
|
|
|
|
|
=head1 AUTHOR - Peter Dimitrov |
66
|
|
|
|
|
|
|
|
67
|
|
|
|
|
|
|
Email dimitrov@gnf.org |
68
|
|
|
|
|
|
|
|
69
|
|
|
|
|
|
|
=head1 CONTRIBUTORS |
70
|
|
|
|
|
|
|
|
71
|
|
|
|
|
|
|
Hilmar Lapp, hlapp at gmx.net |
72
|
|
|
|
|
|
|
|
73
|
|
|
|
|
|
|
=head1 APPENDIX |
74
|
|
|
|
|
|
|
|
75
|
|
|
|
|
|
|
The rest of the documentation details each of the object methods. |
76
|
|
|
|
|
|
|
Internal methods are usually preceded with a _ |
77
|
|
|
|
|
|
|
|
78
|
|
|
|
|
|
|
=cut |
79
|
|
|
|
|
|
|
|
80
|
|
|
|
|
|
|
# Let the code begin... |
81
|
|
|
|
|
|
|
|
82
|
|
|
|
|
|
|
package Bio::Ontology::SimpleOntologyEngine; |
83
|
1
|
|
|
1
|
|
809
|
use strict; |
|
1
|
|
|
|
|
2
|
|
|
1
|
|
|
|
|
23
|
|
84
|
1
|
|
|
1
|
|
4
|
use Carp; |
|
1
|
|
|
|
|
1
|
|
|
1
|
|
|
|
|
44
|
|
85
|
1
|
|
|
1
|
|
215
|
use Bio::Ontology::RelationshipFactory; |
|
1
|
|
|
|
|
2
|
|
|
1
|
|
|
|
|
21
|
|
86
|
1
|
|
|
1
|
|
5
|
use Data::Dumper; |
|
1
|
|
|
|
|
2
|
|
|
1
|
|
|
|
|
36
|
|
87
|
|
|
|
|
|
|
|
88
|
1
|
|
|
1
|
|
4
|
use base qw(Bio::Root::Root Bio::Ontology::OntologyEngineI); |
|
1
|
|
|
|
|
2
|
|
|
1
|
|
|
|
|
2086
|
|
89
|
|
|
|
|
|
|
|
90
|
|
|
|
|
|
|
=head2 new |
91
|
|
|
|
|
|
|
|
92
|
|
|
|
|
|
|
Title : new |
93
|
|
|
|
|
|
|
Usage : $soe = Bio::Ontology::SimpleOntologyEngine->new; |
94
|
|
|
|
|
|
|
Function: Initializes the ontology engine. |
95
|
|
|
|
|
|
|
Example : $soe = Bio::Ontology::SimpleOntologyEngine->new; |
96
|
|
|
|
|
|
|
Returns : Object of class SimpleOntologyEngine. |
97
|
|
|
|
|
|
|
Args : |
98
|
|
|
|
|
|
|
|
99
|
|
|
|
|
|
|
=cut |
100
|
|
|
|
|
|
|
|
101
|
|
|
|
|
|
|
sub new { |
102
|
1
|
|
|
1
|
1
|
7
|
my ( $class, @args ) = @_; |
103
|
1
|
|
|
|
|
5
|
my $self = $class->SUPER::new(@args); |
104
|
|
|
|
|
|
|
|
105
|
|
|
|
|
|
|
# my %param = @args; |
106
|
|
|
|
|
|
|
|
107
|
1
|
|
|
|
|
4
|
$self->_term_store( {} ); |
108
|
1
|
|
|
|
|
3
|
$self->_relationship_store( {} ); |
109
|
1
|
|
|
|
|
9
|
$self->_inverted_relationship_store( {} ); |
110
|
1
|
|
|
|
|
2
|
$self->_relationship_type_store( {} ); |
111
|
1
|
|
|
|
|
3
|
$self->_instantiated_terms_store( {} ); |
112
|
|
|
|
|
|
|
|
113
|
|
|
|
|
|
|
# set defaults for the factories |
114
|
1
|
|
|
|
|
5
|
$self->relationship_factory( |
115
|
|
|
|
|
|
|
Bio::Ontology::RelationshipFactory->new( -type => "Bio::Ontology::Relationship" ) ); |
116
|
1
|
|
|
|
|
2
|
return $self; |
117
|
|
|
|
|
|
|
} |
118
|
|
|
|
|
|
|
|
119
|
|
|
|
|
|
|
=head2 _instantiated_terms_store |
120
|
|
|
|
|
|
|
|
121
|
|
|
|
|
|
|
Title : _instantiated_terms_store |
122
|
|
|
|
|
|
|
Usage : $obj->_instantiated_terms_store($newval) |
123
|
|
|
|
|
|
|
Function: |
124
|
|
|
|
|
|
|
Example : |
125
|
|
|
|
|
|
|
Returns : hash |
126
|
|
|
|
|
|
|
Args : empty hash |
127
|
|
|
|
|
|
|
|
128
|
|
|
|
|
|
|
=cut |
129
|
|
|
|
|
|
|
|
130
|
|
|
|
|
|
|
sub _instantiated_terms_store { |
131
|
24
|
|
|
24
|
|
32
|
my ( $self, $value ) = @_; |
132
|
|
|
|
|
|
|
|
133
|
24
|
100
|
|
|
|
30
|
if ( defined $value ) { |
134
|
1
|
|
|
|
|
2
|
$self->{'_instantiated_terms_store'} = $value; |
135
|
|
|
|
|
|
|
} |
136
|
24
|
|
|
|
|
46
|
return $self->{'_instantiated_terms_store'}; |
137
|
|
|
|
|
|
|
} |
138
|
|
|
|
|
|
|
|
139
|
|
|
|
|
|
|
=head2 mark_instantiated |
140
|
|
|
|
|
|
|
|
141
|
|
|
|
|
|
|
Title : mark_instantiated |
142
|
|
|
|
|
|
|
Usage : $self->mark_instantiated(TermI terms): TermI |
143
|
|
|
|
|
|
|
Function: Marks TermI objects as fully instantiated, |
144
|
|
|
|
|
|
|
allowing for proper counting of the number of terms in the term store. |
145
|
|
|
|
|
|
|
The TermI objects has to be already stored in the term store in order |
146
|
|
|
|
|
|
|
to be marked. |
147
|
|
|
|
|
|
|
Example : $self->mark_instantiated($term); |
148
|
|
|
|
|
|
|
Returns : its argument or throws an exception if a term is not |
149
|
|
|
|
|
|
|
in the term store. |
150
|
|
|
|
|
|
|
Args : array of objects of class TermI. |
151
|
|
|
|
|
|
|
|
152
|
|
|
|
|
|
|
=cut |
153
|
|
|
|
|
|
|
|
154
|
|
|
|
|
|
|
sub mark_instantiated { |
155
|
0
|
|
|
0
|
1
|
0
|
my ( $self, @terms ) = @_; |
156
|
|
|
|
|
|
|
|
157
|
0
|
|
|
|
|
0
|
foreach my $term (@terms) { |
158
|
|
|
|
|
|
|
$self->throw( "term " . $term->identifier . " not in the term store\n" ) |
159
|
0
|
0
|
|
|
|
0
|
if !defined $self->_term_store->{ $term->identifier }; |
160
|
0
|
|
|
|
|
0
|
$self->_instantiated_terms_store->{ $term->identifier } = 1; |
161
|
|
|
|
|
|
|
} |
162
|
|
|
|
|
|
|
|
163
|
0
|
|
|
|
|
0
|
return @terms; |
164
|
|
|
|
|
|
|
} |
165
|
|
|
|
|
|
|
|
166
|
|
|
|
|
|
|
=head2 mark_uninstantiated |
167
|
|
|
|
|
|
|
|
168
|
|
|
|
|
|
|
Title : mark_uninstantiated |
169
|
|
|
|
|
|
|
Usage : $self->mark_uninstantiated(TermI terms): TermI |
170
|
|
|
|
|
|
|
Function: Marks TermI objects as not fully instantiated, |
171
|
|
|
|
|
|
|
Example : $self->mark_uninstantiated($term); |
172
|
|
|
|
|
|
|
Returns : its argument or throws an exception if a term is not |
173
|
|
|
|
|
|
|
in the term store(if the term is not marked it does nothing). |
174
|
|
|
|
|
|
|
Args : array of objects of class TermI. |
175
|
|
|
|
|
|
|
|
176
|
|
|
|
|
|
|
=cut |
177
|
|
|
|
|
|
|
|
178
|
|
|
|
|
|
|
sub mark_uninstantiated { |
179
|
0
|
|
|
0
|
1
|
0
|
my ( $self, @terms ) = @_; |
180
|
|
|
|
|
|
|
|
181
|
0
|
|
|
|
|
0
|
foreach my $term (@terms) { |
182
|
|
|
|
|
|
|
$self->throw( "term " . $term->identifier . " not in the term store\n" ) |
183
|
0
|
0
|
|
|
|
0
|
if !defined $self->_term_store->{ $term->identifier }; |
184
|
|
|
|
|
|
|
delete $self->_instantiated_terms_store->{ $term->identifier } |
185
|
0
|
0
|
|
|
|
0
|
if defined $self->_instantiated_terms_store->{ $term->identifier }; |
186
|
|
|
|
|
|
|
} |
187
|
|
|
|
|
|
|
|
188
|
0
|
|
|
|
|
0
|
return @terms; |
189
|
|
|
|
|
|
|
} |
190
|
|
|
|
|
|
|
|
191
|
|
|
|
|
|
|
=head2 _term_store |
192
|
|
|
|
|
|
|
|
193
|
|
|
|
|
|
|
Title : term_store |
194
|
|
|
|
|
|
|
Usage : $obj->_term_store($newval) |
195
|
|
|
|
|
|
|
Function: |
196
|
|
|
|
|
|
|
Example : |
197
|
|
|
|
|
|
|
Returns : reference to an array of Bio::Ontology::TermI objects |
198
|
|
|
|
|
|
|
Args : reference to an array of Bio::Ontology::TermI objects |
199
|
|
|
|
|
|
|
|
200
|
|
|
|
|
|
|
=cut |
201
|
|
|
|
|
|
|
|
202
|
|
|
|
|
|
|
sub _term_store { |
203
|
28
|
|
|
28
|
|
34
|
my ( $self, $value ) = @_; |
204
|
|
|
|
|
|
|
|
205
|
28
|
100
|
|
|
|
38
|
if ( defined $value ) { |
206
|
1
|
50
|
|
|
|
6
|
if ( defined $self->{'_term_store'} ) { |
207
|
0
|
|
|
|
|
0
|
$self->throw("_term_store already defined\n"); |
208
|
|
|
|
|
|
|
} else { |
209
|
1
|
|
|
|
|
2
|
$self->{'_term_store'} = $value; |
210
|
|
|
|
|
|
|
} |
211
|
|
|
|
|
|
|
} |
212
|
|
|
|
|
|
|
|
213
|
28
|
|
|
|
|
38
|
return $self->{'_term_store'}; |
214
|
|
|
|
|
|
|
} |
215
|
|
|
|
|
|
|
|
216
|
|
|
|
|
|
|
=head2 add_term |
217
|
|
|
|
|
|
|
|
218
|
|
|
|
|
|
|
Title : add_term |
219
|
|
|
|
|
|
|
Usage : add_term(TermI term): TermI |
220
|
|
|
|
|
|
|
Function: Adds TermI object to the ontology engine term store. |
221
|
|
|
|
|
|
|
Marks the term fully instantiated by default. |
222
|
|
|
|
|
|
|
Example : $soe->add_term($term) |
223
|
|
|
|
|
|
|
Returns : its argument. |
224
|
|
|
|
|
|
|
Args : object of class TermI. |
225
|
|
|
|
|
|
|
|
226
|
|
|
|
|
|
|
=cut |
227
|
|
|
|
|
|
|
|
228
|
|
|
|
|
|
|
sub add_term { |
229
|
4
|
|
|
4
|
1
|
6
|
my ( $self, $term ) = @_; |
230
|
4
|
|
|
|
|
6
|
my $term_store = $self->_term_store; |
231
|
|
|
|
|
|
|
|
232
|
4
|
50
|
33
|
|
|
8
|
if ( defined $term_store->{ $term->identifier } && $self->_instantiated_terms_store->{ $term->identifier }) { |
233
|
0
|
|
|
|
|
0
|
$self->throw( "term " . $term->identifier . " already defined\n" ); |
234
|
|
|
|
|
|
|
} else { |
235
|
4
|
|
|
|
|
6
|
$term_store->{ $term->identifier } = $term; |
236
|
4
|
|
|
|
|
8
|
$self->_instantiated_terms_store->{ $term->identifier } = 1; |
237
|
|
|
|
|
|
|
} |
238
|
|
|
|
|
|
|
|
239
|
4
|
|
|
|
|
9
|
return $term; |
240
|
|
|
|
|
|
|
} |
241
|
|
|
|
|
|
|
|
242
|
|
|
|
|
|
|
=head2 get_term_by_identifier |
243
|
|
|
|
|
|
|
|
244
|
|
|
|
|
|
|
Title : get_term_by_identifier |
245
|
|
|
|
|
|
|
Usage : get_term_by_identifier(String id): TermI |
246
|
|
|
|
|
|
|
Function: Retrieves terms from the term store by their identifier |
247
|
|
|
|
|
|
|
field, or an empty list if not there. |
248
|
|
|
|
|
|
|
Example : $term = $soe->get_term_by_identifier("IPR000001"); |
249
|
|
|
|
|
|
|
Returns : An array of zero or more Bio::Ontology::TermI objects. |
250
|
|
|
|
|
|
|
Args : An array of identifier strings |
251
|
|
|
|
|
|
|
|
252
|
|
|
|
|
|
|
=cut |
253
|
|
|
|
|
|
|
|
254
|
|
|
|
|
|
|
sub get_term_by_identifier { |
255
|
10
|
|
|
10
|
1
|
18
|
my ( $self, @ids ) = @_; |
256
|
10
|
|
|
|
|
11
|
my @ans = (); |
257
|
|
|
|
|
|
|
|
258
|
10
|
|
|
|
|
12
|
foreach my $id (@ids) { |
259
|
21
|
|
|
|
|
27
|
my $term = $self->_term_store->{$id}; |
260
|
21
|
50
|
|
|
|
35
|
push @ans, $term if defined $term; |
261
|
|
|
|
|
|
|
} |
262
|
|
|
|
|
|
|
|
263
|
10
|
|
|
|
|
22
|
return @ans; |
264
|
|
|
|
|
|
|
} |
265
|
|
|
|
|
|
|
|
266
|
|
|
|
|
|
|
=head2 _get_number_rels |
267
|
|
|
|
|
|
|
|
268
|
|
|
|
|
|
|
Title : get_number_rels |
269
|
|
|
|
|
|
|
Usage : |
270
|
|
|
|
|
|
|
Function: |
271
|
|
|
|
|
|
|
Example : |
272
|
|
|
|
|
|
|
Returns : |
273
|
|
|
|
|
|
|
Args : |
274
|
|
|
|
|
|
|
|
275
|
|
|
|
|
|
|
=cut |
276
|
|
|
|
|
|
|
|
277
|
|
|
|
|
|
|
sub _get_number_rels { |
278
|
0
|
|
|
0
|
|
0
|
my ($self) = @_; |
279
|
0
|
|
|
|
|
0
|
my $num_rels = 0; |
280
|
|
|
|
|
|
|
|
281
|
0
|
|
|
|
|
0
|
foreach my $entry ( $self->_relationship_store ) { |
282
|
0
|
|
|
|
|
0
|
$num_rels += scalar keys %$entry; |
283
|
|
|
|
|
|
|
} |
284
|
0
|
|
|
|
|
0
|
return $num_rels; |
285
|
|
|
|
|
|
|
} |
286
|
|
|
|
|
|
|
|
287
|
|
|
|
|
|
|
=head2 _get_number_terms |
288
|
|
|
|
|
|
|
|
289
|
|
|
|
|
|
|
Title : _get_number_terms |
290
|
|
|
|
|
|
|
Usage : |
291
|
|
|
|
|
|
|
Function: |
292
|
|
|
|
|
|
|
Example : |
293
|
|
|
|
|
|
|
Returns : |
294
|
|
|
|
|
|
|
Args : |
295
|
|
|
|
|
|
|
|
296
|
|
|
|
|
|
|
=cut |
297
|
|
|
|
|
|
|
|
298
|
|
|
|
|
|
|
sub _get_number_terms { |
299
|
0
|
|
|
0
|
|
0
|
my ($self) = @_; |
300
|
|
|
|
|
|
|
|
301
|
0
|
|
|
|
|
0
|
return scalar $self->_filter_unmarked( values %{ $self->_term_store } ); |
|
0
|
|
|
|
|
0
|
|
302
|
|
|
|
|
|
|
|
303
|
|
|
|
|
|
|
} |
304
|
|
|
|
|
|
|
|
305
|
|
|
|
|
|
|
=head2 _relationship_store |
306
|
|
|
|
|
|
|
|
307
|
|
|
|
|
|
|
Title : _storerelationship_store |
308
|
|
|
|
|
|
|
Usage : $obj->relationship_store($newval) |
309
|
|
|
|
|
|
|
Function: |
310
|
|
|
|
|
|
|
Example : |
311
|
|
|
|
|
|
|
Returns : reference to an array of Bio::Ontology::TermI objects |
312
|
|
|
|
|
|
|
Args : reference to an array of Bio::Ontology::TermI objects |
313
|
|
|
|
|
|
|
|
314
|
|
|
|
|
|
|
=cut |
315
|
|
|
|
|
|
|
|
316
|
|
|
|
|
|
|
sub _relationship_store { |
317
|
19
|
|
|
19
|
|
28
|
my ( $self, $value ) = @_; |
318
|
|
|
|
|
|
|
|
319
|
19
|
100
|
|
|
|
32
|
if ( defined $value ) { |
320
|
1
|
50
|
|
|
|
3
|
if ( defined $self->{'_relationship_store'} ) { |
321
|
0
|
|
|
|
|
0
|
$self->throw("_relationship_store already defined\n"); |
322
|
|
|
|
|
|
|
} else { |
323
|
1
|
|
|
|
|
2
|
$self->{'_relationship_store'} = $value; |
324
|
|
|
|
|
|
|
} |
325
|
|
|
|
|
|
|
} |
326
|
|
|
|
|
|
|
|
327
|
19
|
|
|
|
|
43
|
return $self->{'_relationship_store'}; |
328
|
|
|
|
|
|
|
} |
329
|
|
|
|
|
|
|
|
330
|
|
|
|
|
|
|
=head2 _inverted_relationship_store |
331
|
|
|
|
|
|
|
|
332
|
|
|
|
|
|
|
Title : _inverted_relationship_store |
333
|
|
|
|
|
|
|
Usage : |
334
|
|
|
|
|
|
|
Function: |
335
|
|
|
|
|
|
|
Example : |
336
|
|
|
|
|
|
|
Returns : reference to an array of Bio::Ontology::TermI objects |
337
|
|
|
|
|
|
|
Args : reference to an array of Bio::Ontology::TermI objects |
338
|
|
|
|
|
|
|
|
339
|
|
|
|
|
|
|
=cut |
340
|
|
|
|
|
|
|
|
341
|
|
|
|
|
|
|
sub _inverted_relationship_store { |
342
|
13
|
|
|
13
|
|
17
|
my ( $self, $value ) = @_; |
343
|
|
|
|
|
|
|
|
344
|
13
|
100
|
|
|
|
20
|
if ( defined $value ) { |
345
|
1
|
50
|
|
|
|
2
|
if ( defined $self->{'_inverted_relationship_store'} ) { |
346
|
0
|
|
|
|
|
0
|
$self->throw("_inverted_relationship_store already defined\n"); |
347
|
|
|
|
|
|
|
} else { |
348
|
1
|
|
|
|
|
2
|
$self->{'_inverted_relationship_store'} = $value; |
349
|
|
|
|
|
|
|
} |
350
|
|
|
|
|
|
|
} |
351
|
|
|
|
|
|
|
|
352
|
13
|
|
|
|
|
24
|
return $self->{'_inverted_relationship_store'}; |
353
|
|
|
|
|
|
|
} |
354
|
|
|
|
|
|
|
|
355
|
|
|
|
|
|
|
=head2 _relationship_type_store |
356
|
|
|
|
|
|
|
|
357
|
|
|
|
|
|
|
Title : _relationship_type_store |
358
|
|
|
|
|
|
|
Usage : $obj->_relationship_type_store($newval) |
359
|
|
|
|
|
|
|
Function: |
360
|
|
|
|
|
|
|
Example : |
361
|
|
|
|
|
|
|
Returns : reference to an array of Bio::Ontology::RelationshipType objects |
362
|
|
|
|
|
|
|
Args : reference to an array of Bio::Ontology::RelationshipType objects |
363
|
|
|
|
|
|
|
|
364
|
|
|
|
|
|
|
=cut |
365
|
|
|
|
|
|
|
|
366
|
|
|
|
|
|
|
sub _relationship_type_store { |
367
|
5
|
|
|
5
|
|
6
|
my ( $self, $value ) = @_; |
368
|
|
|
|
|
|
|
|
369
|
5
|
100
|
|
|
|
8
|
if ( defined $value ) { |
370
|
1
|
50
|
|
|
|
2
|
if ( defined $self->{'_relationship_type_store'} ) { |
371
|
0
|
|
|
|
|
0
|
$self->throw("_relationship_type_store already defined\n"); |
372
|
|
|
|
|
|
|
} else { |
373
|
1
|
|
|
|
|
2
|
$self->{'_relationship_type_store'} = $value; |
374
|
|
|
|
|
|
|
} |
375
|
|
|
|
|
|
|
} |
376
|
|
|
|
|
|
|
|
377
|
5
|
|
|
|
|
9
|
return $self->{'_relationship_type_store'}; |
378
|
|
|
|
|
|
|
} |
379
|
|
|
|
|
|
|
|
380
|
|
|
|
|
|
|
=head2 _add_relationship_simple |
381
|
|
|
|
|
|
|
|
382
|
|
|
|
|
|
|
Title : _add_relationship_simple |
383
|
|
|
|
|
|
|
Usage : |
384
|
|
|
|
|
|
|
Function: |
385
|
|
|
|
|
|
|
Example : |
386
|
|
|
|
|
|
|
Returns : |
387
|
|
|
|
|
|
|
Args : |
388
|
|
|
|
|
|
|
|
389
|
|
|
|
|
|
|
=cut |
390
|
|
|
|
|
|
|
|
391
|
|
|
|
|
|
|
sub _add_relationship_simple { |
392
|
12
|
|
|
12
|
|
16
|
my ( $self, $store, $rel, $inverted ) = @_; |
393
|
|
|
|
|
|
|
|
394
|
12
|
100
|
|
|
|
21
|
my $subject = $rel->subject_term |
395
|
|
|
|
|
|
|
or $self->throw('cannot add relationship, relationship has no subject_term'); |
396
|
10
|
100
|
|
|
|
17
|
my $object = $rel->object_term |
397
|
|
|
|
|
|
|
or $self->throw('cannot add relationship, relationship has no object_term'); |
398
|
|
|
|
|
|
|
|
399
|
8
|
|
|
|
|
12
|
my ( $parent_id, $child_id ) = ( $object->identifier, $subject->identifier ); |
400
|
8
|
100
|
|
|
|
16
|
( $parent_id, $child_id ) = ( $child_id, $parent_id ) if $inverted; |
401
|
|
|
|
|
|
|
|
402
|
8
|
50
|
66
|
|
|
19
|
if ( defined $store->{$parent_id} |
|
|
|
33
|
|
|
|
|
403
|
|
|
|
|
|
|
&& defined $store->{$parent_id}->{$child_id} |
404
|
|
|
|
|
|
|
&& $store->{$parent_id}->{$child_id}->name ne $rel->predicate_term->name |
405
|
|
|
|
|
|
|
) { |
406
|
|
|
|
|
|
|
$self->throw( "relationship " |
407
|
|
|
|
|
|
|
. $rel->predicate_term->name |
408
|
|
|
|
|
|
|
. " between " |
409
|
|
|
|
|
|
|
. $parent_id . " and " |
410
|
|
|
|
|
|
|
. $child_id |
411
|
|
|
|
|
|
|
. " already defined as " |
412
|
0
|
|
|
|
|
0
|
. $store->{$parent_id}->{$child_id}->name |
413
|
|
|
|
|
|
|
. "\n" ); |
414
|
|
|
|
|
|
|
} |
415
|
|
|
|
|
|
|
|
416
|
|
|
|
|
|
|
# all is well if we get here |
417
|
8
|
|
|
|
|
13
|
$store->{$parent_id}->{$child_id} = $rel->predicate_term; |
418
|
|
|
|
|
|
|
} |
419
|
|
|
|
|
|
|
|
420
|
|
|
|
|
|
|
=head2 add_relationship |
421
|
|
|
|
|
|
|
|
422
|
|
|
|
|
|
|
Title : add_relationship |
423
|
|
|
|
|
|
|
Usage : add_relationship(RelationshipI relationship): RelationshipI |
424
|
|
|
|
|
|
|
Function: Adds a relationship object to the ontology engine. |
425
|
|
|
|
|
|
|
Example : |
426
|
|
|
|
|
|
|
Returns : Its argument. |
427
|
|
|
|
|
|
|
Args : A RelationshipI object. |
428
|
|
|
|
|
|
|
|
429
|
|
|
|
|
|
|
=cut |
430
|
|
|
|
|
|
|
|
431
|
|
|
|
|
|
|
sub add_relationship { |
432
|
8
|
|
|
8
|
1
|
12
|
my ( $self, $rel ) = @_; |
433
|
|
|
|
|
|
|
|
434
|
8
|
|
|
|
|
14
|
$self->_add_relationship_simple( $self->_relationship_store, $rel, 0 ); |
435
|
4
|
|
|
|
|
6
|
$self->_add_relationship_simple( $self->_inverted_relationship_store, $rel, 1 ); |
436
|
4
|
|
|
|
|
7
|
$self->_relationship_type_store->{ $self->_unique_termid( $rel->predicate_term ) } = |
437
|
|
|
|
|
|
|
$rel->predicate_term; |
438
|
|
|
|
|
|
|
|
439
|
4
|
|
|
|
|
9
|
return $rel; |
440
|
|
|
|
|
|
|
} |
441
|
|
|
|
|
|
|
|
442
|
|
|
|
|
|
|
=head2 get_relationships |
443
|
|
|
|
|
|
|
|
444
|
|
|
|
|
|
|
Title : get_relationships |
445
|
|
|
|
|
|
|
Usage : get_relationships(): RelationshipI |
446
|
|
|
|
|
|
|
Function: Retrieves all relationship objects. |
447
|
|
|
|
|
|
|
Example : |
448
|
|
|
|
|
|
|
Returns : Array of RelationshipI objects |
449
|
|
|
|
|
|
|
Args : |
450
|
|
|
|
|
|
|
|
451
|
|
|
|
|
|
|
=cut |
452
|
|
|
|
|
|
|
|
453
|
|
|
|
|
|
|
sub get_relationships { |
454
|
0
|
|
|
0
|
1
|
0
|
my $self = shift; |
455
|
0
|
|
|
|
|
0
|
my $term = shift; |
456
|
0
|
|
|
|
|
0
|
my @rels; |
457
|
0
|
|
|
|
|
0
|
my $store = $self->_relationship_store; |
458
|
0
|
|
|
|
|
0
|
my $relfact = $self->relationship_factory(); |
459
|
|
|
|
|
|
|
|
460
|
|
|
|
|
|
|
my @parent_ids = $term |
461
|
|
|
|
|
|
|
? |
462
|
|
|
|
|
|
|
|
463
|
|
|
|
|
|
|
# if a term is supplied then only get the term's parents |
464
|
0
|
|
|
|
|
0
|
( map { $_->identifier(); } $self->get_parent_terms($term) ) |
465
|
|
|
|
|
|
|
: |
466
|
|
|
|
|
|
|
|
467
|
|
|
|
|
|
|
# otherwise use all parent ids |
468
|
0
|
0
|
|
|
|
0
|
( keys %{$store} ); |
|
0
|
|
|
|
|
0
|
|
469
|
|
|
|
|
|
|
|
470
|
|
|
|
|
|
|
# add the term as a parent too if one is supplied |
471
|
0
|
0
|
|
|
|
0
|
push( @parent_ids, $term->identifier ) if $term; |
472
|
|
|
|
|
|
|
|
473
|
0
|
|
|
|
|
0
|
foreach my $parent_id (@parent_ids) { |
474
|
0
|
|
|
|
|
0
|
my $parent_entry = $store->{$parent_id}; |
475
|
|
|
|
|
|
|
|
476
|
|
|
|
|
|
|
# if a term is supplied, add a relationship for the parent to the term |
477
|
|
|
|
|
|
|
# except if the parent is the term itself (we added that one before) |
478
|
0
|
0
|
0
|
|
|
0
|
if ( $term && ( $parent_id ne $term->identifier() ) ) { |
479
|
0
|
|
|
|
|
0
|
my @parent_terms = $self->get_term_by_identifier($parent_id); |
480
|
0
|
|
|
|
|
0
|
foreach my $parent_term (@parent_terms) { |
481
|
|
|
|
|
|
|
push( |
482
|
|
|
|
|
|
|
@rels, |
483
|
|
|
|
|
|
|
$relfact->create_object( |
484
|
|
|
|
|
|
|
-object_term => $parent_term, |
485
|
|
|
|
|
|
|
-subject_term => $term, |
486
|
0
|
|
|
|
|
0
|
-predicate_term => $parent_entry->{ $term->identifier }, |
487
|
|
|
|
|
|
|
-ontology => $term->ontology() |
488
|
|
|
|
|
|
|
) |
489
|
|
|
|
|
|
|
); |
490
|
|
|
|
|
|
|
} |
491
|
|
|
|
|
|
|
|
492
|
|
|
|
|
|
|
} else { |
493
|
|
|
|
|
|
|
|
494
|
|
|
|
|
|
|
# otherwise, i.e., no term supplied, or the parent equals the |
495
|
|
|
|
|
|
|
# supplied term |
496
|
0
|
0
|
|
|
|
0
|
my @parent_terms = $term ? ($term) : $self->get_term_by_identifier($parent_id); |
497
|
0
|
|
|
|
|
0
|
foreach my $child_id ( keys %$parent_entry ) { |
498
|
0
|
|
|
|
|
0
|
my $rel_info = $parent_entry->{$child_id}; |
499
|
0
|
|
|
|
|
0
|
my ($subj_term) = $self->get_term_by_identifier($child_id); |
500
|
|
|
|
|
|
|
|
501
|
0
|
|
|
|
|
0
|
foreach my $parent_term (@parent_terms) { |
502
|
0
|
|
|
|
|
0
|
push( |
503
|
|
|
|
|
|
|
@rels, |
504
|
|
|
|
|
|
|
$relfact->create_object( |
505
|
|
|
|
|
|
|
-object_term => $parent_term, |
506
|
|
|
|
|
|
|
-subject_term => $subj_term, |
507
|
|
|
|
|
|
|
-predicate_term => $rel_info, |
508
|
|
|
|
|
|
|
-ontology => $parent_term->ontology |
509
|
|
|
|
|
|
|
) |
510
|
|
|
|
|
|
|
); |
511
|
|
|
|
|
|
|
} |
512
|
|
|
|
|
|
|
} |
513
|
|
|
|
|
|
|
} |
514
|
|
|
|
|
|
|
} |
515
|
|
|
|
|
|
|
|
516
|
0
|
|
|
|
|
0
|
return @rels; |
517
|
|
|
|
|
|
|
} |
518
|
|
|
|
|
|
|
|
519
|
|
|
|
|
|
|
=head2 get_all_relationships |
520
|
|
|
|
|
|
|
|
521
|
|
|
|
|
|
|
Title : get_all_relationships |
522
|
|
|
|
|
|
|
Usage : get_all_relationships(): RelationshipI |
523
|
|
|
|
|
|
|
Function: Retrieves all relationship objects. |
524
|
|
|
|
|
|
|
Example : |
525
|
|
|
|
|
|
|
Returns : Array of RelationshipI objects |
526
|
|
|
|
|
|
|
Args : |
527
|
|
|
|
|
|
|
|
528
|
|
|
|
|
|
|
=cut |
529
|
|
|
|
|
|
|
|
530
|
|
|
|
|
|
|
sub get_all_relationships { |
531
|
0
|
|
|
0
|
1
|
0
|
return shift->get_relationships(); |
532
|
|
|
|
|
|
|
} |
533
|
|
|
|
|
|
|
|
534
|
|
|
|
|
|
|
=head2 get_predicate_terms |
535
|
|
|
|
|
|
|
|
536
|
|
|
|
|
|
|
Title : get_predicate_terms |
537
|
|
|
|
|
|
|
Usage : get_predicate_terms(): TermI |
538
|
|
|
|
|
|
|
Function: Retrieves all relationship types stored in the engine |
539
|
|
|
|
|
|
|
Example : |
540
|
|
|
|
|
|
|
Returns : reference to an array of Bio::Ontology::RelationshipType objects |
541
|
|
|
|
|
|
|
Args : |
542
|
|
|
|
|
|
|
|
543
|
|
|
|
|
|
|
=cut |
544
|
|
|
|
|
|
|
|
545
|
|
|
|
|
|
|
sub get_predicate_terms { |
546
|
0
|
|
|
0
|
1
|
0
|
my ($self) = @_; |
547
|
|
|
|
|
|
|
|
548
|
0
|
|
|
|
|
0
|
return values %{ $self->_relationship_type_store }; |
|
0
|
|
|
|
|
0
|
|
549
|
|
|
|
|
|
|
} |
550
|
|
|
|
|
|
|
|
551
|
|
|
|
|
|
|
=head2 _is_rel_type |
552
|
|
|
|
|
|
|
|
553
|
|
|
|
|
|
|
Title : _is_rel_type |
554
|
|
|
|
|
|
|
Usage : |
555
|
|
|
|
|
|
|
Function: |
556
|
|
|
|
|
|
|
Example : |
557
|
|
|
|
|
|
|
Returns : |
558
|
|
|
|
|
|
|
Args : |
559
|
|
|
|
|
|
|
|
560
|
|
|
|
|
|
|
=cut |
561
|
|
|
|
|
|
|
|
562
|
|
|
|
|
|
|
sub _is_rel_type { |
563
|
16
|
|
|
16
|
|
19
|
my ( $self, $term, @rel_types ) = @_; |
564
|
|
|
|
|
|
|
|
565
|
16
|
|
|
|
|
18
|
foreach my $rel_type (@rel_types) { |
566
|
16
|
50
|
33
|
|
|
32
|
if ( $rel_type->identifier || $term->identifier ) { |
567
|
0
|
0
|
|
|
|
0
|
return 1 if $rel_type->identifier eq $term->identifier; |
568
|
|
|
|
|
|
|
} else { |
569
|
16
|
100
|
|
|
|
23
|
return 1 if $rel_type->name eq $term->name; |
570
|
|
|
|
|
|
|
} |
571
|
|
|
|
|
|
|
} |
572
|
|
|
|
|
|
|
|
573
|
6
|
|
|
|
|
12
|
return 0; |
574
|
|
|
|
|
|
|
} |
575
|
|
|
|
|
|
|
|
576
|
|
|
|
|
|
|
=head2 _typed_traversal |
577
|
|
|
|
|
|
|
|
578
|
|
|
|
|
|
|
Title : _typed_traversal |
579
|
|
|
|
|
|
|
Usage : |
580
|
|
|
|
|
|
|
Function: |
581
|
|
|
|
|
|
|
Example : |
582
|
|
|
|
|
|
|
Returns : |
583
|
|
|
|
|
|
|
Args : |
584
|
|
|
|
|
|
|
|
585
|
|
|
|
|
|
|
=cut |
586
|
|
|
|
|
|
|
|
587
|
|
|
|
|
|
|
sub _typed_traversal { |
588
|
18
|
|
|
18
|
|
27
|
my ( $self, $rel_store, $level, $term_id, @rel_types ) = @_; |
589
|
18
|
50
|
|
|
|
31
|
return if !defined( $rel_store->{$term_id} ); |
590
|
18
|
|
|
|
|
18
|
my %parent_entry = %{ $rel_store->{$term_id} }; |
|
18
|
|
|
|
|
40
|
|
591
|
18
|
|
|
|
|
34
|
my @children = keys %parent_entry; |
592
|
|
|
|
|
|
|
|
593
|
18
|
|
|
|
|
18
|
my @ans; |
594
|
|
|
|
|
|
|
|
595
|
18
|
100
|
|
|
|
31
|
if ( @rel_types > 0 ) { |
596
|
10
|
|
|
|
|
10
|
@ans = (); |
597
|
|
|
|
|
|
|
|
598
|
10
|
|
|
|
|
11
|
foreach my $child_id (@children) { |
599
|
|
|
|
|
|
|
push @ans, $child_id |
600
|
16
|
100
|
|
|
|
28
|
if $self->_is_rel_type( $rel_store->{$term_id}->{$child_id}, @rel_types ); |
601
|
|
|
|
|
|
|
} |
602
|
|
|
|
|
|
|
} else { |
603
|
8
|
|
|
|
|
10
|
@ans = @children; |
604
|
|
|
|
|
|
|
} |
605
|
18
|
100
|
|
|
|
31
|
if ( $level < 1 ) { |
606
|
14
|
|
|
|
|
55
|
my @ans1 = (); |
607
|
|
|
|
|
|
|
|
608
|
14
|
|
|
|
|
15
|
foreach my $child_id (@ans) { |
609
|
|
|
|
|
|
|
push @ans1, $self->_typed_traversal( $rel_store, $level - 1, $child_id, @rel_types ) |
610
|
16
|
100
|
|
|
|
37
|
if defined $rel_store->{$child_id}; |
611
|
|
|
|
|
|
|
} |
612
|
14
|
|
|
|
|
47
|
push @ans, @ans1; |
613
|
|
|
|
|
|
|
} |
614
|
|
|
|
|
|
|
|
615
|
18
|
|
|
|
|
44
|
return @ans; |
616
|
|
|
|
|
|
|
} |
617
|
|
|
|
|
|
|
|
618
|
|
|
|
|
|
|
=head2 get_child_terms |
619
|
|
|
|
|
|
|
|
620
|
|
|
|
|
|
|
Title : get_child_terms |
621
|
|
|
|
|
|
|
Usage : get_child_terms(TermI term, TermI predicate_terms): TermI |
622
|
|
|
|
|
|
|
get_child_terms(TermI term, RelationshipType predicate_terms): TermI |
623
|
|
|
|
|
|
|
Function: Retrieves all child terms of a given term, that satisfy a |
624
|
|
|
|
|
|
|
relationship among those that are specified in the second |
625
|
|
|
|
|
|
|
argument or undef otherwise. get_child_terms is a special |
626
|
|
|
|
|
|
|
case of get_descendant_terms, limiting the search to the |
627
|
|
|
|
|
|
|
direct descendants. |
628
|
|
|
|
|
|
|
Example : |
629
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
630
|
|
|
|
|
|
|
Args : First argument is the term of interest, second is the list of |
631
|
|
|
|
|
|
|
relationship type terms. |
632
|
|
|
|
|
|
|
|
633
|
|
|
|
|
|
|
=cut |
634
|
|
|
|
|
|
|
|
635
|
|
|
|
|
|
|
sub get_child_terms { |
636
|
3
|
|
|
3
|
1
|
6
|
my ( $self, $term, @relationship_types ) = @_; |
637
|
|
|
|
|
|
|
|
638
|
3
|
50
|
33
|
|
|
29
|
$self->throw("must provide TermI compliant object") |
639
|
|
|
|
|
|
|
unless defined($term) && $term->isa("Bio::Ontology::TermI"); |
640
|
|
|
|
|
|
|
|
641
|
3
|
|
|
|
|
7
|
return $self->_filter_unmarked( |
642
|
|
|
|
|
|
|
$self->get_term_by_identifier( |
643
|
|
|
|
|
|
|
$self->_typed_traversal( |
644
|
|
|
|
|
|
|
$self->_relationship_store, 1, $term->identifier, @relationship_types |
645
|
|
|
|
|
|
|
) |
646
|
|
|
|
|
|
|
) |
647
|
|
|
|
|
|
|
); |
648
|
|
|
|
|
|
|
} |
649
|
|
|
|
|
|
|
|
650
|
|
|
|
|
|
|
=head2 get_descendant_terms |
651
|
|
|
|
|
|
|
|
652
|
|
|
|
|
|
|
Title : get_descendant_terms |
653
|
|
|
|
|
|
|
Usage : get_descendant_terms(TermI term, TermI rel_types): TermI |
654
|
|
|
|
|
|
|
get_child_terms(TermI term, RelationshipType predicate_terms): TermI |
655
|
|
|
|
|
|
|
Function: Retrieves all descendant terms of a given term, that |
656
|
|
|
|
|
|
|
satisfy a relationship among those that are specified in |
657
|
|
|
|
|
|
|
the second argument or undef otherwise. Uses |
658
|
|
|
|
|
|
|
_typed_traversal to find all descendants. |
659
|
|
|
|
|
|
|
|
660
|
|
|
|
|
|
|
Example : |
661
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
662
|
|
|
|
|
|
|
Args : First argument is the term of interest, second is the list of |
663
|
|
|
|
|
|
|
relationship type terms. |
664
|
|
|
|
|
|
|
|
665
|
|
|
|
|
|
|
=cut |
666
|
|
|
|
|
|
|
|
667
|
|
|
|
|
|
|
sub get_descendant_terms { |
668
|
3
|
|
|
3
|
1
|
6
|
my ( $self, $term, @relationship_types ) = @_; |
669
|
|
|
|
|
|
|
|
670
|
3
|
50
|
33
|
|
|
15
|
$self->throw("must provide TermI compliant object") |
671
|
|
|
|
|
|
|
unless defined($term) && $term->isa("Bio::Ontology::TermI"); |
672
|
|
|
|
|
|
|
|
673
|
3
|
|
|
|
|
8
|
return $self->_filter_unmarked( |
674
|
|
|
|
|
|
|
$self->_filter_repeated( |
675
|
|
|
|
|
|
|
$self->get_term_by_identifier( |
676
|
|
|
|
|
|
|
$self->_typed_traversal( |
677
|
|
|
|
|
|
|
$self->_relationship_store, 0, $term->identifier, @relationship_types |
678
|
|
|
|
|
|
|
) |
679
|
|
|
|
|
|
|
) |
680
|
|
|
|
|
|
|
) |
681
|
|
|
|
|
|
|
); |
682
|
|
|
|
|
|
|
} |
683
|
|
|
|
|
|
|
|
684
|
|
|
|
|
|
|
=head2 get_parent_terms |
685
|
|
|
|
|
|
|
|
686
|
|
|
|
|
|
|
Title : get_parent_terms |
687
|
|
|
|
|
|
|
Usage : get_parent_terms(TermI term, TermI predicate_terms): TermI |
688
|
|
|
|
|
|
|
get_child_terms(TermI term, RelationshipType predicate_terms): TermI |
689
|
|
|
|
|
|
|
Function: Retrieves all parent terms of a given term, that satisfy a |
690
|
|
|
|
|
|
|
relationship among those that are specified in the second |
691
|
|
|
|
|
|
|
argument or undef otherwise. get_parent_terms is a special |
692
|
|
|
|
|
|
|
case of get_ancestor_terms, limiting the search to the |
693
|
|
|
|
|
|
|
direct ancestors. |
694
|
|
|
|
|
|
|
|
695
|
|
|
|
|
|
|
Example : |
696
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
697
|
|
|
|
|
|
|
Args : First argument is the term of interest, second is the list of relationship type terms. |
698
|
|
|
|
|
|
|
|
699
|
|
|
|
|
|
|
=cut |
700
|
|
|
|
|
|
|
|
701
|
|
|
|
|
|
|
sub get_parent_terms { |
702
|
1
|
|
|
1
|
1
|
3
|
my ( $self, $term, @relationship_types ) = @_; |
703
|
1
|
50
|
|
|
|
3
|
$self->throw("term must be a valid object, not undef") unless defined $term; |
704
|
|
|
|
|
|
|
|
705
|
1
|
|
|
|
|
3
|
return $self->_filter_unmarked( |
706
|
|
|
|
|
|
|
$self->get_term_by_identifier( |
707
|
|
|
|
|
|
|
$self->_typed_traversal( |
708
|
|
|
|
|
|
|
$self->_inverted_relationship_store, |
709
|
|
|
|
|
|
|
1, $term->identifier, @relationship_types |
710
|
|
|
|
|
|
|
) |
711
|
|
|
|
|
|
|
) |
712
|
|
|
|
|
|
|
); |
713
|
|
|
|
|
|
|
} |
714
|
|
|
|
|
|
|
|
715
|
|
|
|
|
|
|
=head2 get_ancestor_terms |
716
|
|
|
|
|
|
|
|
717
|
|
|
|
|
|
|
Title : get_ancestor_terms |
718
|
|
|
|
|
|
|
Usage : get_ancestor_terms(TermI term, TermI predicate_terms): TermI |
719
|
|
|
|
|
|
|
get_child_terms(TermI term, RelationshipType predicate_terms): TermI |
720
|
|
|
|
|
|
|
Function: Retrieves all ancestor terms of a given term, that satisfy |
721
|
|
|
|
|
|
|
a relationship among those that are specified in the second |
722
|
|
|
|
|
|
|
argument or undef otherwise. Uses _typed_traversal to find |
723
|
|
|
|
|
|
|
all ancestors. |
724
|
|
|
|
|
|
|
|
725
|
|
|
|
|
|
|
Example : |
726
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
727
|
|
|
|
|
|
|
Args : First argument is the term of interest, second is the list |
728
|
|
|
|
|
|
|
of relationship type terms. |
729
|
|
|
|
|
|
|
|
730
|
|
|
|
|
|
|
=cut |
731
|
|
|
|
|
|
|
|
732
|
|
|
|
|
|
|
sub get_ancestor_terms { |
733
|
3
|
|
|
3
|
1
|
6
|
my ( $self, $term, @relationship_types ) = @_; |
734
|
3
|
50
|
|
|
|
6
|
$self->throw("term must be a valid object, not undef") unless defined $term; |
735
|
|
|
|
|
|
|
|
736
|
3
|
|
|
|
|
7
|
return $self->_filter_unmarked( |
737
|
|
|
|
|
|
|
$self->_filter_repeated( |
738
|
|
|
|
|
|
|
$self->get_term_by_identifier( |
739
|
|
|
|
|
|
|
$self->_typed_traversal( |
740
|
|
|
|
|
|
|
$self->_inverted_relationship_store, 0, |
741
|
|
|
|
|
|
|
$term->identifier, @relationship_types |
742
|
|
|
|
|
|
|
) |
743
|
|
|
|
|
|
|
) |
744
|
|
|
|
|
|
|
) |
745
|
|
|
|
|
|
|
); |
746
|
|
|
|
|
|
|
} |
747
|
|
|
|
|
|
|
|
748
|
|
|
|
|
|
|
=head2 get_leaf_terms |
749
|
|
|
|
|
|
|
|
750
|
|
|
|
|
|
|
Title : get_leaf_terms |
751
|
|
|
|
|
|
|
Usage : get_leaf_terms(): TermI |
752
|
|
|
|
|
|
|
Function: Retrieves all leaf terms from the ontology. Leaf term is a term w/o descendants. |
753
|
|
|
|
|
|
|
Example : @leaf_terms = $obj->get_leaf_terms() |
754
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
755
|
|
|
|
|
|
|
Args : |
756
|
|
|
|
|
|
|
|
757
|
|
|
|
|
|
|
=cut |
758
|
|
|
|
|
|
|
|
759
|
|
|
|
|
|
|
sub get_leaf_terms { |
760
|
1
|
|
|
1
|
1
|
2
|
my ($self) = @_; |
761
|
1
|
|
|
|
|
2
|
my @leaf_terms; |
762
|
|
|
|
|
|
|
|
763
|
1
|
|
|
|
|
2
|
foreach my $term ( values %{ $self->_term_store } ) { |
|
1
|
|
|
|
|
2
|
|
764
|
|
|
|
|
|
|
push @leaf_terms, $term |
765
|
|
|
|
|
|
|
if !defined $self->_relationship_store->{ $term->identifier } |
766
|
4
|
100
|
66
|
|
|
6
|
&& defined $self->_instantiated_terms_store->{ $term->identifier }; |
767
|
|
|
|
|
|
|
} |
768
|
|
|
|
|
|
|
|
769
|
1
|
|
|
|
|
2
|
return @leaf_terms; |
770
|
|
|
|
|
|
|
} |
771
|
|
|
|
|
|
|
|
772
|
|
|
|
|
|
|
=head2 get_root_terms |
773
|
|
|
|
|
|
|
|
774
|
|
|
|
|
|
|
Title : get_root_terms |
775
|
|
|
|
|
|
|
Usage : get_root_terms(): TermI |
776
|
|
|
|
|
|
|
Function: Retrieves all root terms from the ontology. Root term is a term w/o descendants. |
777
|
|
|
|
|
|
|
Example : @root_terms = $obj->get_root_terms() |
778
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
779
|
|
|
|
|
|
|
Args : |
780
|
|
|
|
|
|
|
|
781
|
|
|
|
|
|
|
=cut |
782
|
|
|
|
|
|
|
|
783
|
|
|
|
|
|
|
sub get_root_terms { |
784
|
1
|
|
|
1
|
1
|
2
|
my ($self) = @_; |
785
|
1
|
|
|
|
|
2
|
my @root_terms; |
786
|
|
|
|
|
|
|
|
787
|
1
|
|
|
|
|
2
|
foreach my $term ( values %{ $self->_term_store } ) { |
|
1
|
|
|
|
|
2
|
|
788
|
|
|
|
|
|
|
push @root_terms, $term |
789
|
|
|
|
|
|
|
if !defined $self->_inverted_relationship_store->{ $term->identifier } |
790
|
4
|
100
|
66
|
|
|
7
|
&& defined $self->_instantiated_terms_store->{ $term->identifier }; |
791
|
|
|
|
|
|
|
} |
792
|
|
|
|
|
|
|
|
793
|
1
|
|
|
|
|
3
|
return @root_terms; |
794
|
|
|
|
|
|
|
} |
795
|
|
|
|
|
|
|
|
796
|
|
|
|
|
|
|
=head2 _filter_repeated |
797
|
|
|
|
|
|
|
|
798
|
|
|
|
|
|
|
Title : _filter_repeated |
799
|
|
|
|
|
|
|
Usage : @lst = $self->_filter_repeated(@old_lst); |
800
|
|
|
|
|
|
|
Function: Removes repeated terms |
801
|
|
|
|
|
|
|
Example : |
802
|
|
|
|
|
|
|
Returns : List of unique TermI objects |
803
|
|
|
|
|
|
|
Args : List of TermI objects |
804
|
|
|
|
|
|
|
|
805
|
|
|
|
|
|
|
=cut |
806
|
|
|
|
|
|
|
|
807
|
|
|
|
|
|
|
sub _filter_repeated { |
808
|
6
|
|
|
6
|
|
7
|
my ( $self, @args ) = @_; |
809
|
6
|
|
|
|
|
8
|
my %h; |
810
|
|
|
|
|
|
|
|
811
|
6
|
|
|
|
|
7
|
foreach my $element (@args) { |
812
|
16
|
100
|
|
|
|
24
|
$h{ $element->identifier } = $element if !defined $h{ $element->identifier }; |
813
|
|
|
|
|
|
|
} |
814
|
|
|
|
|
|
|
|
815
|
6
|
|
|
|
|
15
|
return values %h; |
816
|
|
|
|
|
|
|
} |
817
|
|
|
|
|
|
|
|
818
|
|
|
|
|
|
|
=head2 get_all_terms |
819
|
|
|
|
|
|
|
|
820
|
|
|
|
|
|
|
Title : get_all_terms |
821
|
|
|
|
|
|
|
Usage : get_all_terms(): TermI |
822
|
|
|
|
|
|
|
Function: Retrieves all terms currently stored in the ontology. |
823
|
|
|
|
|
|
|
Example : @all_terms = $obj->get_all_terms() |
824
|
|
|
|
|
|
|
Returns : Array of TermI objects. |
825
|
|
|
|
|
|
|
Args : |
826
|
|
|
|
|
|
|
|
827
|
|
|
|
|
|
|
=cut |
828
|
|
|
|
|
|
|
|
829
|
|
|
|
|
|
|
sub get_all_terms { |
830
|
0
|
|
|
0
|
1
|
0
|
my ($self) = @_; |
831
|
|
|
|
|
|
|
|
832
|
0
|
|
|
|
|
0
|
return $self->_filter_unmarked( values %{ $self->_term_store } ); |
|
0
|
|
|
|
|
0
|
|
833
|
|
|
|
|
|
|
} |
834
|
|
|
|
|
|
|
|
835
|
|
|
|
|
|
|
=head2 find_terms |
836
|
|
|
|
|
|
|
|
837
|
|
|
|
|
|
|
Title : find_terms |
838
|
|
|
|
|
|
|
Usage : ($term) = $oe->find_terms(-identifier => "SO:0000263"); |
839
|
|
|
|
|
|
|
Function: Find term instances matching queries for their attributes. |
840
|
|
|
|
|
|
|
|
841
|
|
|
|
|
|
|
This implementation can efficiently resolve queries by |
842
|
|
|
|
|
|
|
identifier. |
843
|
|
|
|
|
|
|
|
844
|
|
|
|
|
|
|
Example : |
845
|
|
|
|
|
|
|
Returns : an array of zero or more Bio::Ontology::TermI objects |
846
|
|
|
|
|
|
|
Args : Named parameters. The following parameters should be recognized |
847
|
|
|
|
|
|
|
by any implementations: |
848
|
|
|
|
|
|
|
|
849
|
|
|
|
|
|
|
-identifier query by the given identifier |
850
|
|
|
|
|
|
|
-name query by the given name |
851
|
|
|
|
|
|
|
|
852
|
|
|
|
|
|
|
=cut |
853
|
|
|
|
|
|
|
|
854
|
|
|
|
|
|
|
sub find_terms { |
855
|
0
|
|
|
0
|
1
|
0
|
my ( $self, @args ) = @_; |
856
|
0
|
|
|
|
|
0
|
my @terms; |
857
|
|
|
|
|
|
|
|
858
|
0
|
|
|
|
|
0
|
my ( $id, $name ) = $self->_rearrange( [qw(IDENTIFIER NAME)], @args ); |
859
|
|
|
|
|
|
|
|
860
|
0
|
0
|
|
|
|
0
|
if ( defined($id) ) { |
861
|
0
|
|
|
|
|
0
|
@terms = $self->get_term_by_identifier($id); |
862
|
|
|
|
|
|
|
} else { |
863
|
0
|
|
|
|
|
0
|
@terms = $self->get_all_terms(); |
864
|
|
|
|
|
|
|
} |
865
|
0
|
0
|
|
|
|
0
|
if ( defined($name) ) { |
866
|
0
|
|
|
|
|
0
|
@terms = grep { $_->name() eq $name; } @terms; |
|
0
|
|
|
|
|
0
|
|
867
|
|
|
|
|
|
|
} |
868
|
0
|
|
|
|
|
0
|
return @terms; |
869
|
|
|
|
|
|
|
} |
870
|
|
|
|
|
|
|
|
871
|
|
|
|
|
|
|
=head2 relationship_factory |
872
|
|
|
|
|
|
|
|
873
|
|
|
|
|
|
|
Title : relationship_factory |
874
|
|
|
|
|
|
|
Usage : $fact = $obj->relationship_factory() |
875
|
|
|
|
|
|
|
Function: Get/set the object factory to be used when relationship |
876
|
|
|
|
|
|
|
objects are created by the implementation on-the-fly. |
877
|
|
|
|
|
|
|
|
878
|
|
|
|
|
|
|
Example : |
879
|
|
|
|
|
|
|
Returns : value of relationship_factory (a Bio::Factory::ObjectFactoryI |
880
|
|
|
|
|
|
|
compliant object) |
881
|
|
|
|
|
|
|
Args : on set, a Bio::Factory::ObjectFactoryI compliant object |
882
|
|
|
|
|
|
|
|
883
|
|
|
|
|
|
|
=cut |
884
|
|
|
|
|
|
|
|
885
|
|
|
|
|
|
|
sub relationship_factory { |
886
|
1
|
|
|
1
|
1
|
2
|
my $self = shift; |
887
|
|
|
|
|
|
|
|
888
|
1
|
50
|
|
|
|
3
|
return $self->{'relationship_factory'} = shift if @_; |
889
|
0
|
|
|
|
|
0
|
return $self->{'relationship_factory'}; |
890
|
|
|
|
|
|
|
} |
891
|
|
|
|
|
|
|
|
892
|
|
|
|
|
|
|
=head2 term_factory |
893
|
|
|
|
|
|
|
|
894
|
|
|
|
|
|
|
Title : term_factory |
895
|
|
|
|
|
|
|
Usage : $fact = $obj->term_factory() |
896
|
|
|
|
|
|
|
Function: Get/set the object factory to be used when term objects are |
897
|
|
|
|
|
|
|
created by the implementation on-the-fly. |
898
|
|
|
|
|
|
|
|
899
|
|
|
|
|
|
|
Note that this ontology engine implementation does not |
900
|
|
|
|
|
|
|
create term objects on the fly, and therefore setting this |
901
|
|
|
|
|
|
|
attribute is meaningless. |
902
|
|
|
|
|
|
|
|
903
|
|
|
|
|
|
|
Example : |
904
|
|
|
|
|
|
|
Returns : value of term_factory (a Bio::Factory::ObjectFactoryI |
905
|
|
|
|
|
|
|
compliant object) |
906
|
|
|
|
|
|
|
Args : on set, a Bio::Factory::ObjectFactoryI compliant object |
907
|
|
|
|
|
|
|
|
908
|
|
|
|
|
|
|
=cut |
909
|
|
|
|
|
|
|
|
910
|
|
|
|
|
|
|
sub term_factory { |
911
|
0
|
|
|
0
|
1
|
0
|
my $self = shift; |
912
|
|
|
|
|
|
|
|
913
|
0
|
0
|
|
|
|
0
|
if (@_) { |
914
|
0
|
|
|
|
|
0
|
$self->warn( |
915
|
|
|
|
|
|
|
"setting term factory, but " . ref($self) . " does not create terms on-the-fly" ); |
916
|
0
|
|
|
|
|
0
|
return $self->{'term_factory'} = shift; |
917
|
|
|
|
|
|
|
} |
918
|
0
|
|
|
|
|
0
|
return $self->{'term_factory'}; |
919
|
|
|
|
|
|
|
} |
920
|
|
|
|
|
|
|
|
921
|
|
|
|
|
|
|
=head2 _filter_unmarked |
922
|
|
|
|
|
|
|
|
923
|
|
|
|
|
|
|
Title : _filter_unmarked |
924
|
|
|
|
|
|
|
Usage : _filter_unmarked(TermI terms): TermI |
925
|
|
|
|
|
|
|
Function: Removes the uninstantiated terms from the list of terms |
926
|
|
|
|
|
|
|
Example : |
927
|
|
|
|
|
|
|
Returns : array of fully instantiated TermI objects |
928
|
|
|
|
|
|
|
Args : array of TermI objects |
929
|
|
|
|
|
|
|
|
930
|
|
|
|
|
|
|
=cut |
931
|
|
|
|
|
|
|
|
932
|
|
|
|
|
|
|
sub _filter_unmarked { |
933
|
10
|
|
|
10
|
|
13
|
my ( $self, @terms ) = @_; |
934
|
10
|
|
|
|
|
14
|
my @filtered_terms = (); |
935
|
|
|
|
|
|
|
|
936
|
10
|
100
|
|
|
|
17
|
if ( scalar(@terms) >= 1 ) { |
937
|
7
|
|
|
|
|
8
|
foreach my $term (@terms) { |
938
|
|
|
|
|
|
|
push @filtered_terms, $term |
939
|
17
|
50
|
|
|
|
27
|
if defined $self->_instantiated_terms_store->{ $term->identifier }; |
940
|
|
|
|
|
|
|
} |
941
|
|
|
|
|
|
|
} |
942
|
|
|
|
|
|
|
|
943
|
10
|
|
|
|
|
80
|
return @filtered_terms; |
944
|
|
|
|
|
|
|
} |
945
|
|
|
|
|
|
|
|
946
|
|
|
|
|
|
|
=head2 remove_term_by_id |
947
|
|
|
|
|
|
|
|
948
|
|
|
|
|
|
|
Title : remove_term_by_id |
949
|
|
|
|
|
|
|
Usage : remove_term_by_id(String id): TermI |
950
|
|
|
|
|
|
|
Function: Removes TermI object from the ontology engine using the |
951
|
|
|
|
|
|
|
string id as an identifier. Current implementation does not |
952
|
|
|
|
|
|
|
enforce consistency of the relationships using that term. |
953
|
|
|
|
|
|
|
Example : $term = $soe->remove_term_by_id($id); |
954
|
|
|
|
|
|
|
Returns : Object of class TermI or undef if not found. |
955
|
|
|
|
|
|
|
Args : The string identifier of a term. |
956
|
|
|
|
|
|
|
|
957
|
|
|
|
|
|
|
=cut |
958
|
|
|
|
|
|
|
|
959
|
|
|
|
|
|
|
sub remove_term_by_id { |
960
|
0
|
|
|
0
|
1
|
0
|
my ( $self, $id ) = @_; |
961
|
|
|
|
|
|
|
|
962
|
0
|
0
|
|
|
|
0
|
if ( $self->get_term_by_identifier($id) ) { |
963
|
0
|
|
|
|
|
0
|
my $term = $self->{_term_store}->{$id}; |
964
|
0
|
|
|
|
|
0
|
delete $self->{_term_store}->{$id}; |
965
|
0
|
|
|
|
|
0
|
return $term; |
966
|
|
|
|
|
|
|
} else { |
967
|
0
|
|
|
|
|
0
|
$self->warn("Term with id '$id' is not in the term store"); |
968
|
0
|
|
|
|
|
0
|
return; |
969
|
|
|
|
|
|
|
} |
970
|
|
|
|
|
|
|
} |
971
|
|
|
|
|
|
|
|
972
|
|
|
|
|
|
|
=head2 to_string |
973
|
|
|
|
|
|
|
|
974
|
|
|
|
|
|
|
Title : to_string |
975
|
|
|
|
|
|
|
Usage : print $sv->to_string(); |
976
|
|
|
|
|
|
|
Function: Currently returns formatted string containing the number of |
977
|
|
|
|
|
|
|
terms and number of relationships from the ontology engine. |
978
|
|
|
|
|
|
|
Example : print $sv->to_string(); |
979
|
|
|
|
|
|
|
Returns : |
980
|
|
|
|
|
|
|
Args : |
981
|
|
|
|
|
|
|
|
982
|
|
|
|
|
|
|
=cut |
983
|
|
|
|
|
|
|
|
984
|
|
|
|
|
|
|
sub to_string { |
985
|
0
|
|
|
0
|
1
|
0
|
my ($self) = @_; |
986
|
0
|
|
|
|
|
0
|
my $s = ""; |
987
|
|
|
|
|
|
|
|
988
|
0
|
|
|
|
|
0
|
$s .= "-- # Terms:\n"; |
989
|
0
|
|
|
|
|
0
|
$s .= scalar( $self->get_all_terms ) . "\n"; |
990
|
0
|
|
|
|
|
0
|
$s .= "-- # Relationships:\n"; |
991
|
0
|
|
|
|
|
0
|
$s .= $self->_get_number_rels . "\n"; |
992
|
|
|
|
|
|
|
|
993
|
0
|
|
|
|
|
0
|
return $s; |
994
|
|
|
|
|
|
|
} |
995
|
|
|
|
|
|
|
|
996
|
|
|
|
|
|
|
=head2 _unique_termid |
997
|
|
|
|
|
|
|
|
998
|
|
|
|
|
|
|
Title : _unique_termid |
999
|
|
|
|
|
|
|
Usage : |
1000
|
|
|
|
|
|
|
Function: Returns a string that can be used as ID using fail-over |
1001
|
|
|
|
|
|
|
approaches. |
1002
|
|
|
|
|
|
|
|
1003
|
|
|
|
|
|
|
If the identifier attribute is not set, it uses the |
1004
|
|
|
|
|
|
|
combination of name and ontology name, provided both are |
1005
|
|
|
|
|
|
|
set. If they are not, it returns the name alone. |
1006
|
|
|
|
|
|
|
|
1007
|
|
|
|
|
|
|
Note that this is a private method. Call from inheriting |
1008
|
|
|
|
|
|
|
classes but not from outside. |
1009
|
|
|
|
|
|
|
|
1010
|
|
|
|
|
|
|
Example : |
1011
|
|
|
|
|
|
|
Returns : a string |
1012
|
|
|
|
|
|
|
Args : a Bio::Ontology::TermI compliant object |
1013
|
|
|
|
|
|
|
|
1014
|
|
|
|
|
|
|
=cut |
1015
|
|
|
|
|
|
|
|
1016
|
|
|
|
|
|
|
sub _unique_termid { |
1017
|
4
|
|
|
4
|
|
5
|
my $self = shift; |
1018
|
4
|
|
|
|
|
4
|
my $term = shift; |
1019
|
|
|
|
|
|
|
|
1020
|
4
|
50
|
|
|
|
8
|
return $term->identifier() if $term->identifier(); |
1021
|
4
|
50
|
|
|
|
8
|
my $id = $term->ontology->name() if $term->ontology(); |
1022
|
4
|
50
|
|
|
|
9
|
if ($id) { |
1023
|
4
|
|
|
|
|
6
|
$id .= '|'; |
1024
|
|
|
|
|
|
|
} else { |
1025
|
0
|
|
|
|
|
0
|
$id = ''; |
1026
|
|
|
|
|
|
|
} |
1027
|
4
|
|
|
|
|
8
|
$id .= $term->name(); |
1028
|
|
|
|
|
|
|
} |
1029
|
|
|
|
|
|
|
|
1030
|
|
|
|
|
|
|
################################################################# |
1031
|
|
|
|
|
|
|
# aliases |
1032
|
|
|
|
|
|
|
################################################################# |
1033
|
|
|
|
|
|
|
|
1034
|
|
|
|
|
|
|
*get_relationship_types = \&get_predicate_terms; |
1035
|
|
|
|
|
|
|
|
1036
|
|
|
|
|
|
|
1; |