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# BioPerl module for Bio::Ontology::RelationshipType |
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# Please direct questions and support issues to |
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# Cared for by Christian M. Zmasek or |
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# |
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# (c) Christian M. Zmasek, czmasek-at-burnham.org, 2002. |
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# (c) GNF, Genomics Institute of the Novartis Research Foundation, 2002. |
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# |
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# You may distribute this module under the same terms as perl itself. |
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# Refer to the Perl Artistic License (see the license accompanying this |
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# software package, or see http://www.perl.com/language/misc/Artistic.html) |
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# for the terms under which you may use, modify, and redistribute this module. |
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# |
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# THIS PACKAGE IS PROVIDED "AS IS" AND WITHOUT ANY EXPRESS OR IMPLIED |
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# WARRANTIES, INCLUDING, WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF |
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# MERCHANTIBILITY AND FITNESS FOR A PARTICULAR PURPOSE. |
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# |
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# You may distribute this module under the same terms as perl itself |
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# POD documentation - main docs before the code |
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=head1 NAME |
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Bio::Ontology::RelationshipType - a relationship type for an ontology |
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=head1 SYNOPSIS |
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# |
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=head1 DESCRIPTION |
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This class can be used to model various types of relationships |
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(such as "IS_A", "PART_OF", "CONTAINS", "FOUND_IN", "RELATED_TO"). |
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This class extends L, so it essentially is-a |
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L. In addition, all methods are overridden such |
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as to make the object immutable. |
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=head1 FEEDBACK |
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=head2 Mailing Lists |
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User feedback is an integral part of the evolution of this and other |
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Bioperl modules. Send your comments and suggestions preferably to the |
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Bioperl mailing lists Your participation is much appreciated. |
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bioperl-l@bioperl.org - General discussion |
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http://bioperl.org/wiki/Mailing_lists - About the mailing lists |
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=head2 Support |
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Please direct usage questions or support issues to the mailing list: |
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I |
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rather than to the module maintainer directly. Many experienced and |
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reponsive experts will be able look at the problem and quickly |
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address it. Please include a thorough description of the problem |
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with code and data examples if at all possible. |
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=head2 Reporting Bugs |
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Report bugs to the Bioperl bug tracking system to help us keep track |
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the bugs and their resolution. Bug reports can be submitted via |
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the web: |
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https://github.com/bioperl/bioperl-live/issues |
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=head1 AUTHOR |
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Christian M. Zmasek |
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Email: czmasek-at-burnham.org or cmzmasek@yahoo.com |
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WWW: http://monochrome-effect.net/ |
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Address: |
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Genomics Institute of the Novartis Research Foundation |
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10675 John Jay Hopkins Drive |
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San Diego, CA 92121 |
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=head1 APPENDIX |
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The rest of the documentation details each of the object |
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methods. Internal methods are usually preceded with a _ |
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=cut |
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# Let the code begin... |
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package Bio::Ontology::RelationshipType; |
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use strict; |
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use constant PART_OF => "PART_OF"; |
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use constant RELATED_TO => "RELATED_TO"; |
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use constant IS_A => "IS_A"; |
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use constant CONTAINS => "CONTAINS"; |
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use constant FOUND_IN => "FOUND_IN"; |
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use constant REGULATES => "REGULATES"; |
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use constant POSITIVELY_REGULATES => "POSITIVELY_REGULATES"; |
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use constant NEGATIVELY_REGULATES => "NEGATIVELY_REGULATES"; |
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use base qw(Bio::Ontology::Term); |
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# |
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# cache for terms |
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# |
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my %term_name_map = (); |
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=head2 get_instance |
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Title : get_instance |
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Usage : $IS_A = Bio::Ontology::RelationshipType->get_instance( "IS_A" ); |
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$PART_OF = Bio::Ontology::RelationshipType->get_instance( "PART_OF" ); |
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$RELATED_TO = Bio::Ontology::RelationshipType->get_instance( "RELATED_TO" ); |
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$CONTAINS = Bio::Ontology::RelationshipType->get_instance( "CONTAINS" ); |
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$FOUND_IN = Bio::Ontology::RelationshipType->get_instance( "FOUND_IN" ); |
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Function: Factory method to create instances of RelationshipType |
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Returns : [Bio::Ontology::RelationshipType] |
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Args : "IS_A" or "PART_OF" or "CONTAINS" or "FOUND_IN" or |
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"RELATED_TO" [scalar] |
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the ontology [Bio::Ontology::OntologyI] (optional) |
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=cut |
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sub get_instance { |
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my ( $class, $name, $ont ) = @_; |
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$class->throw("must provide predicate name") unless $name; |
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# is one in the cache? |
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my $reltype = $term_name_map{$name}; |
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if($reltype && |
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# check whether ontologies match |
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(($ont && $reltype->ontology() && |
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($ont->name() eq $reltype->ontology->name())) || |
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(! ($reltype->ontology() || $ont)))) { |
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# we're done, return cached type |
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return $reltype; |
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} |
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# valid relationship type? |
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# |
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#see the cell ontology. this code is too strict, even for dag-edit files. -allen |
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# |
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# if ( ! (($name eq IS_A) || ($name eq PART_OF) || |
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# ($name eq CONTAINS) || ( $name eq FOUND_IN ))) { |
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# my $msg = "Found unknown type of relationship: [" . $name . "]\n"; |
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# $msg .= "Known types are: [" . IS_A . "], [" . PART_OF . "], [" . CONTAINS . "], [" . FOUND_IN . "]"; |
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# $class->throw( $msg ); |
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# } |
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# if we get here we need to create the rel.type |
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$reltype = $class->new(-name => $name, |
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-ontology => $ont); |
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# cache it (FIXME possibly overrides one from another ontology) |
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$term_name_map{$name} = $reltype; |
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return $reltype; |
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} # get_instance |
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=head2 init |
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Title : init() |
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Usage : $type->init(); |
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Function: Initializes this to all undef and empty lists. |
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Returns : |
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Args : |
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=cut |
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sub init { |
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my $self = shift; |
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$self->SUPER::init(); |
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# at this point we don't really need to do anything special for us |
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} # init |
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=head2 equals |
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Title : equals |
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Usage : if ( $type->equals( $other_type ) ) { ... |
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Function: Compares this type to another one, based on string "eq" of |
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the "identifier" field, if at least one of the two types has |
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the identifier set, or string eq of the name otherwise. |
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Returns : true or false |
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Args : [Bio::Ontology::RelationshipType] |
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199
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=cut |
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201
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sub equals { |
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176
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my( $self, $type ) = @_; |
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$self->_check_class( $type, "Bio::Ontology::RelationshipType" ); |
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if ( $self->identifier() xor $type->identifier() ) { |
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$self->warn("comparing relationship types when only ". |
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"one has an identifier will always return false" ); |
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} |
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return |
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($self->identifier() || $type->identifier()) ? |
213
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|
|
$self->identifier() eq $type->identifier() : |
214
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|
|
$self->name() eq $type->name(); |
215
|
|
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216
|
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|
|
} # equals |
217
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218
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219
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|
|
=head2 identifier |
220
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221
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|
|
Title : identifier |
222
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|
|
Usage : $term->identifier( "IS_A" ); |
223
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|
|
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|
|
|
or |
224
|
|
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|
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|
|
print $term->identifier(); |
225
|
|
|
|
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|
|
Function: Set/get for the immutable identifier of this Type. |
226
|
|
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|
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|
|
Returns : The identifier [scalar]. |
227
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|
Args : The identifier [scalar] (optional). |
228
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229
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|
=cut |
230
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|
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231
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|
|
sub identifier { |
232
|
796
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|
|
796
|
1
|
899
|
my $self = shift; |
233
|
796
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|
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|
|
1058
|
my $ret = $self->SUPER::identifier(); |
234
|
796
|
100
|
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|
|
1122
|
if(@_) { |
235
|
51
|
50
|
33
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|
113
|
$self->throw($self->veto_change("identifier",$ret,$_[0])) |
236
|
|
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|
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|
|
if $ret && ($ret ne $_[0]); |
237
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51
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|
94
|
$ret = $self->SUPER::identifier(@_); |
238
|
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|
} |
239
|
796
|
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|
1581
|
return $ret; |
240
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|
} # identifier |
241
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242
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|
243
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|
|
=head2 name |
244
|
|
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|
|
|
|
|
245
|
|
|
|
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|
|
Title : name |
246
|
|
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|
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|
|
Usage : $term->name( "is a type" ); |
247
|
|
|
|
|
|
|
or |
248
|
|
|
|
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|
|
print $term->name(); |
249
|
|
|
|
|
|
|
Function: Set/get for the immutable name of this Type. |
250
|
|
|
|
|
|
|
Returns : The name [scalar]. |
251
|
|
|
|
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|
|
Args : The name [scalar] (optional). |
252
|
|
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|
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|
|
|
253
|
|
|
|
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|
|
=cut |
254
|
|
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|
|
|
|
|
255
|
|
|
|
|
|
|
sub name { |
256
|
595
|
|
|
595
|
1
|
1485
|
my $self = shift; |
257
|
595
|
|
|
|
|
821
|
my $ret = $self->SUPER::name(); |
258
|
595
|
100
|
|
|
|
866
|
if(@_) { |
259
|
102
|
50
|
33
|
|
|
168
|
$self->throw($self->veto_change("name",$ret,$_[0])) |
260
|
|
|
|
|
|
|
if $ret && ($ret ne $_[0]); |
261
|
102
|
|
|
|
|
159
|
$ret = $self->SUPER::name(@_); |
262
|
|
|
|
|
|
|
} |
263
|
595
|
|
|
|
|
1186
|
return $ret; |
264
|
|
|
|
|
|
|
} # name |
265
|
|
|
|
|
|
|
|
266
|
|
|
|
|
|
|
|
267
|
|
|
|
|
|
|
|
268
|
|
|
|
|
|
|
|
269
|
|
|
|
|
|
|
|
270
|
|
|
|
|
|
|
=head2 definition |
271
|
|
|
|
|
|
|
|
272
|
|
|
|
|
|
|
Title : definition |
273
|
|
|
|
|
|
|
Usage : $term->definition( "" ); |
274
|
|
|
|
|
|
|
or |
275
|
|
|
|
|
|
|
print $term->definition(); |
276
|
|
|
|
|
|
|
Function: Set/get for the immutable definition of this Type. |
277
|
|
|
|
|
|
|
Returns : The definition [scalar]. |
278
|
|
|
|
|
|
|
Args : The definition [scalar] (optional). |
279
|
|
|
|
|
|
|
|
280
|
|
|
|
|
|
|
=cut |
281
|
|
|
|
|
|
|
|
282
|
|
|
|
|
|
|
sub definition { |
283
|
55
|
|
|
55
|
1
|
73
|
my $self = shift; |
284
|
55
|
|
|
|
|
110
|
my $ret = $self->SUPER::definition(); |
285
|
55
|
100
|
|
|
|
127
|
if(@_) { |
286
|
51
|
50
|
33
|
|
|
103
|
$self->veto_change("definition",$ret,$_[0]) |
287
|
|
|
|
|
|
|
if $ret && ($ret ne $_[0]); |
288
|
51
|
|
|
|
|
84
|
$ret = $self->SUPER::definition(@_); |
289
|
|
|
|
|
|
|
} |
290
|
|
|
|
|
|
|
# let's be nice and return something readable here |
291
|
55
|
50
|
|
|
|
104
|
return $ret if $ret; |
292
|
55
|
100
|
|
|
|
85
|
return $self->name()." relationship predicate (type)" if $self->name(); |
293
|
|
|
|
|
|
|
} # definition |
294
|
|
|
|
|
|
|
|
295
|
|
|
|
|
|
|
|
296
|
|
|
|
|
|
|
|
297
|
|
|
|
|
|
|
=head2 ontology |
298
|
|
|
|
|
|
|
|
299
|
|
|
|
|
|
|
Title : ontology |
300
|
|
|
|
|
|
|
Usage : $term->ontology( $top ); |
301
|
|
|
|
|
|
|
or |
302
|
|
|
|
|
|
|
$top = $term->ontology(); |
303
|
|
|
|
|
|
|
Function: Set/get for the ontology this relationship type lives in. |
304
|
|
|
|
|
|
|
Returns : The ontology [Bio::Ontology::OntologyI]. |
305
|
|
|
|
|
|
|
Args : On set, the ontology [Bio::Ontology::OntologyI] (optional). |
306
|
|
|
|
|
|
|
|
307
|
|
|
|
|
|
|
=cut |
308
|
|
|
|
|
|
|
|
309
|
|
|
|
|
|
|
sub ontology { |
310
|
190
|
|
|
190
|
1
|
225
|
my $self = shift; |
311
|
190
|
|
|
|
|
304
|
my $ret = $self->SUPER::ontology(); |
312
|
190
|
100
|
|
|
|
279
|
if(@_) { |
313
|
95
|
|
|
|
|
106
|
my $ont = shift; |
314
|
95
|
50
|
|
|
|
146
|
if($ret) { |
315
|
0
|
0
|
0
|
|
|
0
|
$self->throw($self->veto_change("ontology",$ret->name, |
|
|
0
|
|
|
|
|
|
316
|
|
|
|
|
|
|
$ont ? $ont->name : $ont)) |
317
|
|
|
|
|
|
|
unless $ont && ($ont->name() eq $ret->name()); |
318
|
|
|
|
|
|
|
} |
319
|
95
|
|
|
|
|
146
|
$ret = $self->SUPER::ontology($ont,@_); |
320
|
|
|
|
|
|
|
} |
321
|
190
|
|
|
|
|
384
|
return $ret; |
322
|
|
|
|
|
|
|
} # category |
323
|
|
|
|
|
|
|
|
324
|
|
|
|
|
|
|
|
325
|
|
|
|
|
|
|
|
326
|
|
|
|
|
|
|
=head2 version |
327
|
|
|
|
|
|
|
|
328
|
|
|
|
|
|
|
Title : version |
329
|
|
|
|
|
|
|
Usage : $term->version( "1.00" ); |
330
|
|
|
|
|
|
|
or |
331
|
|
|
|
|
|
|
print $term->version(); |
332
|
|
|
|
|
|
|
Function: Set/get for immutable version information. |
333
|
|
|
|
|
|
|
Returns : The version [scalar]. |
334
|
|
|
|
|
|
|
Args : The version [scalar] (optional). |
335
|
|
|
|
|
|
|
|
336
|
|
|
|
|
|
|
=cut |
337
|
|
|
|
|
|
|
|
338
|
|
|
|
|
|
|
sub version { |
339
|
0
|
|
|
0
|
1
|
0
|
my $self = shift; |
340
|
0
|
|
|
|
|
0
|
my $ret = $self->SUPER::version(); |
341
|
0
|
0
|
|
|
|
0
|
if(@_) { |
342
|
0
|
0
|
0
|
|
|
0
|
$self->throw($self->veto_change("version",$ret,$_[0])) |
343
|
|
|
|
|
|
|
if $ret && ($ret ne $_[0]); |
344
|
0
|
|
|
|
|
0
|
$ret = $self->SUPER::version(@_); |
345
|
|
|
|
|
|
|
} |
346
|
0
|
|
|
|
|
0
|
return $ret; |
347
|
|
|
|
|
|
|
} # version |
348
|
|
|
|
|
|
|
|
349
|
|
|
|
|
|
|
|
350
|
|
|
|
|
|
|
|
351
|
|
|
|
|
|
|
=head2 is_obsolete |
352
|
|
|
|
|
|
|
|
353
|
|
|
|
|
|
|
Title : is_obsolete |
354
|
|
|
|
|
|
|
Usage : $term->is_obsolete( 1 ); |
355
|
|
|
|
|
|
|
or |
356
|
|
|
|
|
|
|
if ( $term->is_obsolete() ) |
357
|
|
|
|
|
|
|
Function: Set/get for the immutable obsoleteness of this Type. |
358
|
|
|
|
|
|
|
Returns : the obsoleteness [0 or 1]. |
359
|
|
|
|
|
|
|
Args : the obsoleteness [0 or 1] (optional). |
360
|
|
|
|
|
|
|
|
361
|
|
|
|
|
|
|
=cut |
362
|
|
|
|
|
|
|
|
363
|
|
|
|
|
|
|
sub is_obsolete { |
364
|
51
|
|
|
51
|
1
|
65
|
my $self = shift; |
365
|
51
|
|
|
|
|
103
|
my $ret = $self->SUPER::is_obsolete(); |
366
|
51
|
50
|
|
|
|
91
|
if(@_) { |
367
|
51
|
50
|
33
|
|
|
100
|
$self->throw($self->veto_change("is_obsolete",$ret,$_[0])) |
368
|
|
|
|
|
|
|
if $ret && ($ret != $_[0]); |
369
|
51
|
|
|
|
|
88
|
$ret = $self->SUPER::is_obsolete(@_); |
370
|
|
|
|
|
|
|
} |
371
|
51
|
|
|
|
|
69
|
return $ret; |
372
|
|
|
|
|
|
|
} # is_obsolete |
373
|
|
|
|
|
|
|
|
374
|
|
|
|
|
|
|
|
375
|
|
|
|
|
|
|
=head2 comment |
376
|
|
|
|
|
|
|
|
377
|
|
|
|
|
|
|
Title : comment |
378
|
|
|
|
|
|
|
Usage : $term->comment( "..." ); |
379
|
|
|
|
|
|
|
or |
380
|
|
|
|
|
|
|
print $term->comment(); |
381
|
|
|
|
|
|
|
Function: Set/get for an arbitrary immutable comment about this Type. |
382
|
|
|
|
|
|
|
Returns : A comment. |
383
|
|
|
|
|
|
|
Args : A comment (optional). |
384
|
|
|
|
|
|
|
|
385
|
|
|
|
|
|
|
=cut |
386
|
|
|
|
|
|
|
|
387
|
|
|
|
|
|
|
sub comment { |
388
|
51
|
|
|
51
|
1
|
80
|
my $self = shift; |
389
|
51
|
|
|
|
|
103
|
my $ret = $self->SUPER::comment(); |
390
|
51
|
50
|
|
|
|
92
|
if(@_) { |
391
|
51
|
50
|
33
|
|
|
97
|
$self->throw($self->veto_change("comment",$ret,$_[0])) |
392
|
|
|
|
|
|
|
if $ret && ($ret ne $_[0]); |
393
|
51
|
|
|
|
|
83
|
$ret = $self->SUPER::comment(@_); |
394
|
|
|
|
|
|
|
} |
395
|
51
|
|
|
|
|
67
|
return $ret; |
396
|
|
|
|
|
|
|
} # comment |
397
|
|
|
|
|
|
|
|
398
|
|
|
|
|
|
|
=head1 Private methods |
399
|
|
|
|
|
|
|
|
400
|
|
|
|
|
|
|
May be overridden in a derived class, but should never be called from |
401
|
|
|
|
|
|
|
outside. |
402
|
|
|
|
|
|
|
|
403
|
|
|
|
|
|
|
=cut |
404
|
|
|
|
|
|
|
|
405
|
|
|
|
|
|
|
sub _check_class { |
406
|
176
|
|
|
176
|
|
235
|
my ( $self, $value, $expected_class ) = @_; |
407
|
|
|
|
|
|
|
|
408
|
176
|
50
|
|
|
|
567
|
if ( ! defined( $value ) ) { |
|
|
50
|
|
|
|
|
|
|
|
50
|
|
|
|
|
|
409
|
0
|
|
|
|
|
|
$self->throw( "Found [undef] where [$expected_class] expected" ); |
410
|
|
|
|
|
|
|
} |
411
|
|
|
|
|
|
|
elsif ( ! ref( $value ) ) { |
412
|
0
|
|
|
|
|
|
$self->throw( "Found [scalar] where [$expected_class] expected" ); |
413
|
|
|
|
|
|
|
} |
414
|
|
|
|
|
|
|
elsif ( ! $value->isa( $expected_class ) ) { |
415
|
0
|
|
|
|
|
|
$self->throw( "Found [" . ref( $value ) . "] where [$expected_class] expected" ); |
416
|
|
|
|
|
|
|
} |
417
|
|
|
|
|
|
|
|
418
|
|
|
|
|
|
|
} # _check_type |
419
|
|
|
|
|
|
|
|
420
|
|
|
|
|
|
|
=head2 veto_change |
421
|
|
|
|
|
|
|
|
422
|
|
|
|
|
|
|
Title : veto_change |
423
|
|
|
|
|
|
|
Usage : |
424
|
|
|
|
|
|
|
Function: Called if an attribute is changed. Setting an attribute is |
425
|
|
|
|
|
|
|
considered a change if it had a value before and the attempt |
426
|
|
|
|
|
|
|
to set it would change the value. |
427
|
|
|
|
|
|
|
|
428
|
|
|
|
|
|
|
This method returns the message to be printed in the exception. |
429
|
|
|
|
|
|
|
|
430
|
|
|
|
|
|
|
Example : |
431
|
|
|
|
|
|
|
Returns : A string |
432
|
|
|
|
|
|
|
Args : The name of the attribute that was attempted to change. |
433
|
|
|
|
|
|
|
Optionally, the old value and the new value for reporting |
434
|
|
|
|
|
|
|
purposes only. |
435
|
|
|
|
|
|
|
|
436
|
|
|
|
|
|
|
=cut |
437
|
|
|
|
|
|
|
|
438
|
|
|
|
|
|
|
sub veto_change{ |
439
|
0
|
|
|
0
|
1
|
|
my ($self,$attr,$old,$new) = @_; |
440
|
|
|
|
|
|
|
|
441
|
0
|
0
|
|
|
|
|
my $changetype = $old ? ($new ? "change" : "unset") : "change"; |
|
|
0
|
|
|
|
|
|
442
|
0
|
|
|
|
|
|
my $msg = "attempt to $changetype attribute $attr in ".ref($self). |
443
|
|
|
|
|
|
|
", which is immutable"; |
444
|
0
|
0
|
0
|
|
|
|
$msg .= " (\"$old\" to \"$new\")" if $old && $new; |
445
|
0
|
|
|
|
|
|
return $msg; |
446
|
|
|
|
|
|
|
} |
447
|
|
|
|
|
|
|
|
448
|
|
|
|
|
|
|
1; |