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# BioPerl module for Bio::Map::PositionI |
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# |
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# Please direct questions and support issues to |
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# |
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# Cared for by Sendu Bala |
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# |
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# Copyright Jason Stajich |
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# |
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# You may distribute this module under the same terms as perl itself |
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# POD documentation - main docs before the code |
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=head1 NAME |
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Bio::Map::PositionI - Abstracts the notion of a position having a value in the context of a marker and a Map |
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=head1 SYNOPSIS |
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# do not use this module directly |
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# See Bio::Map::Position for an example of |
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# implementation. |
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=head1 DESCRIPTION |
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This object stores one of the postions that a mappable object |
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(e.g. Marker) may have in a map. |
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Positions can have non-numeric values or other methods to store the locations, |
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so they have a method numeric() which does the conversion. numeric() |
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returns the position in a form that can be compared between other positions of |
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the same type. It is not necessarily a value suitable for sorting positions (it |
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may be the distance from the previous position); for that purpose the result of |
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sortable() should be used. |
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A 'position', in addition to being a single point, can also be an area and so |
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can be imagined as a range and compared with other positions on the basis of |
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overlap, intersection etc. |
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=head1 FEEDBACK |
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=head2 Mailing Lists |
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User feedback is an integral part of the evolution of this and other |
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Bioperl modules. Send your comments and suggestions preferably to |
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the Bioperl mailing list. Your participation is much appreciated. |
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bioperl-l@bioperl.org - General discussion |
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http://bioperl.org/wiki/Mailing_lists - About the mailing lists |
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=head2 Support |
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Please direct usage questions or support issues to the mailing list: |
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I |
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rather than to the module maintainer directly. Many experienced and |
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reponsive experts will be able look at the problem and quickly |
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address it. Please include a thorough description of the problem |
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with code and data examples if at all possible. |
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=head2 Reporting Bugs |
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Report bugs to the Bioperl bug tracking system to help us keep track |
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of the bugs and their resolution. Bug reports can be submitted via the |
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web: |
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https://github.com/bioperl/bioperl-live/issues |
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=head1 AUTHOR - Jason Stajich |
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Email jason-at-bioperl.org |
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=head1 CONTRIBUTORS |
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Lincoln Stein, lstein-at-cshl.org |
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Heikki Lehvaslaiho, heikki-at-bioperl-dot-org |
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Sendu Bala, bix@sendu.me.uk |
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=head1 APPENDIX |
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The rest of the documentation details each of the object methods. |
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Internal methods are usually preceded with a _ |
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=cut |
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# Let the code begin... |
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package Bio::Map::PositionI; |
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use strict; |
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1441
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use Bio::Map::PositionHandler; |
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use Bio::Map::Mappable; |
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use Scalar::Util qw(looks_like_number); |
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use base qw(Bio::Map::EntityI Bio::RangeI); |
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=head2 EntityI methods |
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These are fundamental to coordination of Positions and other entities, so are |
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implemented at the interface level |
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=cut |
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104
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=head2 get_position_handler |
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Title : get_position_handler |
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Usage : my $position_handler = $entity->get_position_handler(); |
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Function: Gets a PositionHandlerI that $entity is registered with. |
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Returns : Bio::Map::PositionHandlerI object |
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Args : none |
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=cut |
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sub get_position_handler { |
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my $self = shift; |
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unless (defined $self->{_eh}) { |
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my $ph = Bio::Map::PositionHandler->new(-self => $self); |
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$self->{_eh} = $ph; |
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$ph->register; |
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} |
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return $self->{_eh}; |
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} |
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=head2 PositionHandlerI-related methods |
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These are fundamental to coordination of Positions and other entities, so are |
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implemented at the interface level |
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=cut |
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=head2 map |
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Title : map |
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Usage : my $map = $position->map(); |
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$position->map($map); |
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Function: Get/Set the map the position is in. |
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Returns : L |
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Args : none to get |
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new L to set |
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=cut |
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143
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sub map { |
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1
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my ($self, $map) = @_; |
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return $self->get_position_handler->map($map); |
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} |
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=head2 element |
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Title : element |
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Usage : my $element = $position->element(); |
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$position->element($element); |
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Function: Get/Set the element the position is for. |
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Returns : L |
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Args : none to get |
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new L to set |
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158
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=cut |
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160
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sub element { |
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my ($self, $element) = @_; |
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return $self->get_position_handler->element($element); |
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} |
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165
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=head2 marker |
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167
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Title : marker |
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Function: This is a synonym of the element() method |
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Status : deprecated, will be removed in the next version |
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171
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=cut |
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*marker = \&element; |
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175
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=head2 PositionI-specific methods |
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=cut |
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=head2 value |
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181
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Title : value |
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Usage : my $pos = $position->value(); |
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Function: Get/Set the value for this position |
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Returns : scalar, value |
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Args : [optional] new value to set |
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187
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=cut |
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189
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sub value { |
190
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0
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0
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1
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my $self = shift; |
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$self->throw_not_implemented(); |
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} |
193
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194
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=head2 numeric |
195
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196
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Title : numeric |
197
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Usage : my $num = $position->numeric; |
198
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Function: Read-only method that is guaranteed to return a numeric |
199
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representation of the start of this position. |
200
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Returns : scalar numeric |
201
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Args : none to get the co-ordinate normally (see absolute() method), OR |
202
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Bio::Map::RelativeI to get the co-ordinate converted to be |
203
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relative to what this Relative describes. |
204
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205
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=cut |
206
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207
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sub numeric { |
208
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0
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0
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1
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0
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my $self = shift; |
209
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0
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$self->throw_not_implemented(); |
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} |
211
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212
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=head2 sortable |
213
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214
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Title : sortable |
215
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Usage : my $num = $position->sortable(); |
216
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Function: Read-only method that is guaranteed to return a value suitable |
217
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for correctly sorting this kind of position amongst other positions |
218
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of the same kind on the same map. Note that sorting different kinds |
219
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of position together is unlikely to give sane results. |
220
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Returns : numeric |
221
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Args : none |
222
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223
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=cut |
224
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225
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sub sortable { |
226
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0
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0
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1
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0
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my $self = shift; |
227
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0
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0
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$self->throw_not_implemented(); |
228
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} |
229
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230
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=head2 relative |
231
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232
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Title : relative |
233
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Usage : my $relative = $position->relative(); |
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$position->relative($relative); |
235
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Function: Get/set the thing this Position's coordinates (numerical(), start(), |
236
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end()) are relative to, as described by a Relative object. |
237
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Returns : Bio::Map::RelativeI (default is one describing "relative to the |
238
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start of the Position's map") |
239
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Args : none to get, OR |
240
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Bio::Map::RelativeI to set |
241
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242
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=cut |
243
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244
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sub relative { |
245
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0
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0
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1
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0
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my $self = shift; |
246
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0
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0
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$self->throw_not_implemented(); |
247
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} |
248
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249
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=head2 absolute |
250
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251
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Title : absolute |
252
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Usage : my $absolute = $position->absolute(); |
253
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$position->absolute($absolute); |
254
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Function: Get/set how this Position's co-ordinates (numerical(), start(), |
255
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end()) are reported. When absolute is off, co-ordinates are |
256
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relative to the thing described by relative(). Ie. the value |
257
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returned by start() will be the same as the value you set start() |
258
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to. When absolute is on, co-ordinates are converted to be relative |
259
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to the start of the map. |
260
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261
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So if relative() currently points to a Relative object describing |
262
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"relative to another position which is 100 bp from the start of |
263
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the map", this Position's start() had been set to 50 and absolute() |
264
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returns 1, $position->start() will return 150. If absolute() returns |
265
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0 in the same situation, $position->start() would return 50. |
266
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267
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Returns : boolean (default 0) |
268
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Args : none to get, OR |
269
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boolean to set |
270
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271
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=cut |
272
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273
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sub absolute { |
274
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0
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0
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1
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0
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my $self = shift; |
275
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0
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0
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$self->throw_not_implemented(); |
276
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} |
277
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278
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=head2 RangeI-based methods |
279
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280
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=cut |
281
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282
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=head2 start |
283
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284
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Title : start |
285
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Usage : my $start = $position->start(); |
286
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$position->start($start); |
287
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Function: Get/set the start co-ordinate of this position. |
288
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|
Returns : the start of this position |
289
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Args : scalar numeric to set, OR |
290
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none to get the co-ordinate normally (see absolute() method), OR |
291
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Bio::Map::RelativeI to get the co-ordinate converted to be |
292
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relative to what this Relative describes. |
293
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294
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=cut |
295
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296
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=head2 end |
297
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298
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Title : end |
299
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Usage : my $end = $position->end(); |
300
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|
$position->end($end); |
301
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|
Function: Get/set the end co-ordinate of this position. |
302
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|
Returns : the end of this position |
303
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|
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|
|
Args : scalar numeric to set, OR |
304
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|
|
none to get the co-ordinate normally (see absolute() method), OR |
305
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|
Bio::Map::RelativeI to get the co-ordinate converted to be |
306
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|
relative to what this Relative describes. |
307
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308
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=cut |
309
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310
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|
=head2 length |
311
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312
|
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|
Title : length |
313
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|
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|
|
|
|
Usage : $length = $position->length(); |
314
|
|
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|
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|
|
Function: Get the length of this position. |
315
|
|
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|
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|
|
Returns : the length of this position |
316
|
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|
|
Args : none |
317
|
|
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318
|
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|
=cut |
319
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320
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|
=head2 strand |
321
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322
|
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|
|
Title : strand |
323
|
|
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|
|
|
|
Usage : $strand = $position->strand(); |
324
|
|
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|
|
|
|
Function: Get the strand of this position; it is always 1 since maps to not |
325
|
|
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|
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|
|
have strands. |
326
|
|
|
|
|
|
|
Returns : 1 |
327
|
|
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|
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|
|
Args : none |
328
|
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|
|
329
|
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|
|
=cut |
330
|
|
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|
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|
|
331
|
|
|
|
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|
|
sub strand { |
332
|
202
|
|
|
202
|
1
|
383
|
return 1; |
333
|
|
|
|
|
|
|
} |
334
|
|
|
|
|
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|
|
335
|
|
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|
|
|
|
=head2 toString |
336
|
|
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|
|
|
337
|
|
|
|
|
|
|
Title : toString |
338
|
|
|
|
|
|
|
Usage : print $position->toString(), "\n"; |
339
|
|
|
|
|
|
|
Function: stringifies this range |
340
|
|
|
|
|
|
|
Returns : a string representation of the range of this Position |
341
|
|
|
|
|
|
|
Args : optional Bio::Map::RelativeI to have the co-ordinates reported |
342
|
|
|
|
|
|
|
relative to the thing described by that Relative |
343
|
|
|
|
|
|
|
|
344
|
|
|
|
|
|
|
=cut |
345
|
|
|
|
|
|
|
|
346
|
|
|
|
|
|
|
sub toString { |
347
|
0
|
|
|
0
|
1
|
0
|
my $self = shift; |
348
|
0
|
|
|
|
|
0
|
$self->throw_not_implemented(); |
349
|
|
|
|
|
|
|
} |
350
|
|
|
|
|
|
|
|
351
|
|
|
|
|
|
|
=head1 RangeI-related methods |
352
|
|
|
|
|
|
|
|
353
|
|
|
|
|
|
|
These methods work by considering only the values of start() and end(), as |
354
|
|
|
|
|
|
|
modified by considering every such co-ordinate relative to the start of the map |
355
|
|
|
|
|
|
|
(ie. absolute(1) is set temporarily during the calculation), or any supplied |
356
|
|
|
|
|
|
|
Relative. For the boolean methods, when the comparison Position is on the same |
357
|
|
|
|
|
|
|
map as the calling Position, there is no point supplying a Relative since the |
358
|
|
|
|
|
|
|
answer will be the same as without. Relative is most useful when comparing |
359
|
|
|
|
|
|
|
Positions on different maps and you have a Relative that describes some special |
360
|
|
|
|
|
|
|
place on each map like 'the start of the gene', where the actual start of the |
361
|
|
|
|
|
|
|
gene relative to the start of the map is different for each map. |
362
|
|
|
|
|
|
|
|
363
|
|
|
|
|
|
|
The methods do not consider maps during their calculations - things on different |
364
|
|
|
|
|
|
|
maps can overlap/contain/intersect/etc. each other. |
365
|
|
|
|
|
|
|
|
366
|
|
|
|
|
|
|
The geometrical methods (intersect, union etc.) do things to the geometry of |
367
|
|
|
|
|
|
|
ranges, and return Bio::Map::PositionI compliant objects or triplets (start, |
368
|
|
|
|
|
|
|
stop, strand) from which new positions could be built. When a PositionI is made |
369
|
|
|
|
|
|
|
it will have a map transferred to it if all the arguments shared the same map. |
370
|
|
|
|
|
|
|
If a Relative was supplied the result will have that same Relative. |
371
|
|
|
|
|
|
|
|
372
|
|
|
|
|
|
|
Note that the strand-testing args are there for compatibility with the RangeI |
373
|
|
|
|
|
|
|
interface. They have no meaning when only using PositionI objects since maps do |
374
|
|
|
|
|
|
|
not have strands. Typically you will just set the argument to undef if you want |
375
|
|
|
|
|
|
|
to supply the argument after it. |
376
|
|
|
|
|
|
|
|
377
|
|
|
|
|
|
|
=head2 equals |
378
|
|
|
|
|
|
|
|
379
|
|
|
|
|
|
|
Title : equals |
380
|
|
|
|
|
|
|
Usage : if ($p1->equals($p2)) {...} |
381
|
|
|
|
|
|
|
Function: Test whether $p1 has the same start, end, length as $p2. |
382
|
|
|
|
|
|
|
Returns : true if they are describing the same position (regardless of map) |
383
|
|
|
|
|
|
|
Args : arg #1 = a Bio::RangeI (eg. a Bio::Map::Position) to compare this |
384
|
|
|
|
|
|
|
one to (mandatory) |
385
|
|
|
|
|
|
|
arg #2 = optional strand-testing arg ('strong', 'weak', 'ignore') |
386
|
|
|
|
|
|
|
arg #3 = optional Bio::Map::RelativeI to ask if the Positions |
387
|
|
|
|
|
|
|
equal in terms of their relative position to the thing |
388
|
|
|
|
|
|
|
described by that Relative |
389
|
|
|
|
|
|
|
|
390
|
|
|
|
|
|
|
=cut |
391
|
|
|
|
|
|
|
|
392
|
|
|
|
|
|
|
sub equals { |
393
|
|
|
|
|
|
|
# overriding the RangeI implementation so we can handle Relative |
394
|
8
|
|
|
8
|
1
|
498
|
my ($self, $other, $so, $rel) = @_; |
395
|
|
|
|
|
|
|
|
396
|
8
|
|
|
|
|
29
|
my ($own_start, $own_end) = $self->_pre_rangei($self, $rel); |
397
|
8
|
|
|
|
|
17
|
my ($other_start, $other_end) = $self->_pre_rangei($other, $rel); |
398
|
|
|
|
|
|
|
|
399
|
8
|
|
66
|
|
|
30
|
return ($self->_testStrand($other, $so) and |
400
|
|
|
|
|
|
|
$own_start == $other_start and $own_end == $other_end); |
401
|
|
|
|
|
|
|
} |
402
|
|
|
|
|
|
|
|
403
|
|
|
|
|
|
|
|
404
|
|
|
|
|
|
|
=head2 less_than |
405
|
|
|
|
|
|
|
|
406
|
|
|
|
|
|
|
Title : less_than |
407
|
|
|
|
|
|
|
Usage : if ($position->less_than($other_position)) {...} |
408
|
|
|
|
|
|
|
Function: Ask if this Position ends before another starts. |
409
|
|
|
|
|
|
|
Returns : boolean |
410
|
|
|
|
|
|
|
Args : arg #1 = a Bio::RangeI (eg. a Bio::Map::Position) to compare this |
411
|
|
|
|
|
|
|
one to (mandatory) |
412
|
|
|
|
|
|
|
arg #2 = optional Bio::Map::RelativeI to ask if the Position is less |
413
|
|
|
|
|
|
|
in terms of their relative position to the thing described |
414
|
|
|
|
|
|
|
by that Relative |
415
|
|
|
|
|
|
|
|
416
|
|
|
|
|
|
|
=cut |
417
|
|
|
|
|
|
|
|
418
|
|
|
|
|
|
|
sub less_than { |
419
|
3
|
|
|
3
|
1
|
4
|
my ($self, $other, $rel) = @_; |
420
|
|
|
|
|
|
|
|
421
|
3
|
|
|
|
|
9
|
my ($own_start, $own_end) = $self->_pre_rangei($self, $rel); |
422
|
3
|
|
|
|
|
7
|
my ($other_start, $other_end) = $self->_pre_rangei($other, $rel); |
423
|
|
|
|
|
|
|
|
424
|
3
|
|
|
|
|
11
|
return $own_end < $other_start; |
425
|
|
|
|
|
|
|
} |
426
|
|
|
|
|
|
|
|
427
|
|
|
|
|
|
|
=head2 greater_than |
428
|
|
|
|
|
|
|
|
429
|
|
|
|
|
|
|
Title : greater_than |
430
|
|
|
|
|
|
|
Usage : if ($position->greater_than($other_position)) {...} |
431
|
|
|
|
|
|
|
Function: Ask if this Position starts after another ends. |
432
|
|
|
|
|
|
|
Returns : boolean |
433
|
|
|
|
|
|
|
Args : arg #1 = a Bio::RangeI (eg. a Bio::Map::Position) to compare this |
434
|
|
|
|
|
|
|
one to (mandatory) |
435
|
|
|
|
|
|
|
arg #2 = optional Bio::Map::RelativeI to ask if the Position is |
436
|
|
|
|
|
|
|
greater in terms of their relative position to the thing |
437
|
|
|
|
|
|
|
described by that Relative |
438
|
|
|
|
|
|
|
|
439
|
|
|
|
|
|
|
=cut |
440
|
|
|
|
|
|
|
|
441
|
|
|
|
|
|
|
sub greater_than { |
442
|
4
|
|
|
4
|
1
|
7
|
my ($self, $other, $rel) = @_; |
443
|
|
|
|
|
|
|
|
444
|
4
|
|
|
|
|
9
|
my ($own_start, $own_end) = $self->_pre_rangei($self, $rel); |
445
|
4
|
|
|
|
|
8
|
my ($other_start, $other_end) = $self->_pre_rangei($other, $rel); |
446
|
|
|
|
|
|
|
|
447
|
4
|
|
|
|
|
10
|
return $own_start > $other_end; |
448
|
|
|
|
|
|
|
} |
449
|
|
|
|
|
|
|
|
450
|
|
|
|
|
|
|
=head2 overlaps |
451
|
|
|
|
|
|
|
|
452
|
|
|
|
|
|
|
Title : overlaps |
453
|
|
|
|
|
|
|
Usage : if ($p1->overlaps($p2)) {...} |
454
|
|
|
|
|
|
|
Function: Tests if $p1 overlaps $p2. |
455
|
|
|
|
|
|
|
Returns : True if the positions overlap (regardless of map), false otherwise |
456
|
|
|
|
|
|
|
Args : arg #1 = a Bio::RangeI (eg. a Bio::Map::Position) to compare this |
457
|
|
|
|
|
|
|
one to (mandatory) |
458
|
|
|
|
|
|
|
arg #2 = optional strand-testing arg ('strong', 'weak', 'ignore') |
459
|
|
|
|
|
|
|
arg #3 = optional Bio::Map::RelativeI to ask if the Positions |
460
|
|
|
|
|
|
|
overlap in terms of their relative position to the thing |
461
|
|
|
|
|
|
|
described by that Relative |
462
|
|
|
|
|
|
|
arg #4 = optional minimum percentage length of the overlap before |
463
|
|
|
|
|
|
|
reporting an overlap exists (default 0) |
464
|
|
|
|
|
|
|
|
465
|
|
|
|
|
|
|
=cut |
466
|
|
|
|
|
|
|
|
467
|
|
|
|
|
|
|
sub overlaps { |
468
|
|
|
|
|
|
|
# overriding the RangeI implementation so we can handle Relative |
469
|
171
|
|
|
171
|
1
|
177
|
my ($self, $other, $so, $rel, $min_percent) = @_; |
470
|
171
|
|
50
|
|
|
406
|
$min_percent ||= 0; |
471
|
|
|
|
|
|
|
|
472
|
171
|
|
|
|
|
143
|
my ($own_min, $other_min) = (0, 0); |
473
|
171
|
50
|
|
|
|
221
|
if ($min_percent > 0) { |
474
|
0
|
|
|
|
|
0
|
$own_min = (($self->length / 100) * $min_percent) - 1; |
475
|
0
|
|
|
|
|
0
|
$other_min = (($other->length / 100) * $min_percent) - 1; |
476
|
|
|
|
|
|
|
} |
477
|
|
|
|
|
|
|
|
478
|
171
|
|
|
|
|
211
|
my ($own_start, $own_end) = $self->_pre_rangei($self, $rel); |
479
|
171
|
|
|
|
|
248
|
my ($other_start, $other_end) = $self->_pre_rangei($other, $rel); |
480
|
|
|
|
|
|
|
|
481
|
171
|
|
66
|
|
|
342
|
return ($self->_testStrand($other, $so) and not |
482
|
|
|
|
|
|
|
(($own_start + $own_min > $other_end or $own_end - $own_min < $other_start) || |
483
|
|
|
|
|
|
|
($own_start > $other_end - $other_min or $own_end < $other_start + $other_min))); |
484
|
|
|
|
|
|
|
} |
485
|
|
|
|
|
|
|
|
486
|
|
|
|
|
|
|
=head2 contains |
487
|
|
|
|
|
|
|
|
488
|
|
|
|
|
|
|
Title : contains |
489
|
|
|
|
|
|
|
Usage : if ($p1->contains($p2)) {...} |
490
|
|
|
|
|
|
|
Function: Tests whether $p1 totally contains $p2. |
491
|
|
|
|
|
|
|
Returns : true if the argument is totally contained within this position |
492
|
|
|
|
|
|
|
(regardless of map), false otherwise |
493
|
|
|
|
|
|
|
Args : arg #1 = a Bio::RangeI (eg. a Bio::Map::Position) to compare this |
494
|
|
|
|
|
|
|
one to, or scalar number (mandatory) |
495
|
|
|
|
|
|
|
arg #2 = optional strand-testing arg ('strong', 'weak', 'ignore') |
496
|
|
|
|
|
|
|
arg #3 = optional Bio::Map::RelativeI to ask if the Position |
497
|
|
|
|
|
|
|
is contained in terms of their relative position to the |
498
|
|
|
|
|
|
|
thing described by that Relative |
499
|
|
|
|
|
|
|
|
500
|
|
|
|
|
|
|
=cut |
501
|
|
|
|
|
|
|
|
502
|
|
|
|
|
|
|
sub contains { |
503
|
|
|
|
|
|
|
# overriding the RangeI implementation so we can handle Relative |
504
|
12
|
|
|
12
|
1
|
18
|
my ($self, $other, $so, $rel) = @_; |
505
|
|
|
|
|
|
|
|
506
|
12
|
|
|
|
|
32
|
my ($own_start, $own_end) = $self->_pre_rangei($self, $rel); |
507
|
12
|
|
|
|
|
25
|
my ($other_start, $other_end) = $self->_pre_rangei($other, $rel); |
508
|
|
|
|
|
|
|
|
509
|
12
|
|
100
|
|
|
39
|
return ($self->_testStrand($other, $so) and |
510
|
|
|
|
|
|
|
$other_start >= $own_start and $other_end <= $own_end); |
511
|
|
|
|
|
|
|
} |
512
|
|
|
|
|
|
|
|
513
|
|
|
|
|
|
|
=head2 intersection |
514
|
|
|
|
|
|
|
|
515
|
|
|
|
|
|
|
Title : intersection |
516
|
|
|
|
|
|
|
Usage : ($start, $stop, $strand) = $p1->intersection($p2) |
517
|
|
|
|
|
|
|
($start, $stop, $strand) = Bio::Map::Position->intersection(\@positions); |
518
|
|
|
|
|
|
|
$mappable = $p1->intersection($p2, undef, $relative); |
519
|
|
|
|
|
|
|
$mappable = Bio::Map::Position->intersection(\@positions); |
520
|
|
|
|
|
|
|
Function: gives the range that is contained by all ranges |
521
|
|
|
|
|
|
|
Returns : undef if they do not overlap, OR |
522
|
|
|
|
|
|
|
Bio::Map::Mappable object who's positions are the |
523
|
|
|
|
|
|
|
cross-map-calculated intersection of the input positions on all the |
524
|
|
|
|
|
|
|
maps that the input positions belong to, OR, in list context, a three |
525
|
|
|
|
|
|
|
element array (start, end, strand) |
526
|
|
|
|
|
|
|
Args : arg #1 = [REQUIRED] a Bio::RangeI (eg. a Bio::Map::Position) to |
527
|
|
|
|
|
|
|
compare this one to, or an array ref of Bio::RangeI |
528
|
|
|
|
|
|
|
arg #2 = optional strand-testing arg ('strong', 'weak', 'ignore') |
529
|
|
|
|
|
|
|
arg #3 = optional Bio::Map::RelativeI to ask how the Positions |
530
|
|
|
|
|
|
|
intersect in terms of their relative position to the thing |
531
|
|
|
|
|
|
|
described by that Relative |
532
|
|
|
|
|
|
|
|
533
|
|
|
|
|
|
|
=cut |
534
|
|
|
|
|
|
|
|
535
|
|
|
|
|
|
|
sub intersection { |
536
|
|
|
|
|
|
|
# overriding the RangeI implementation so we can transfer map and handle |
537
|
|
|
|
|
|
|
# Relative |
538
|
4
|
|
|
4
|
1
|
8
|
my ($self, $given, $so, $rel) = @_; |
539
|
4
|
50
|
|
|
|
12
|
$self->throw("missing arg: you need to pass in another argument") unless $given; |
540
|
|
|
|
|
|
|
|
541
|
4
|
|
|
|
|
5
|
my @positions; |
542
|
4
|
50
|
|
|
|
14
|
if ($self eq "Bio::Map::PositionI") { |
543
|
0
|
|
|
|
|
0
|
$self = "Bio::Map::Position"; |
544
|
0
|
|
|
|
|
0
|
$self->warn("calling static methods of an interface is deprecated; use $self instead"); |
545
|
|
|
|
|
|
|
} |
546
|
4
|
50
|
|
|
|
10
|
if (ref $self) { |
547
|
4
|
|
|
|
|
5
|
push(@positions, $self); |
548
|
|
|
|
|
|
|
} |
549
|
4
|
100
|
|
|
|
12
|
ref($given) eq 'ARRAY' ? push(@positions, @{$given}) : push(@positions, $given); |
|
2
|
|
|
|
|
4
|
|
550
|
4
|
50
|
|
|
|
10
|
$self->throw("Need at least 2 Positions") unless @positions >= 2; |
551
|
|
|
|
|
|
|
|
552
|
4
|
|
|
|
|
5
|
my ($intersect, $i_start, $i_end, $c_start, $c_end, %known_maps); |
553
|
4
|
|
|
|
|
13
|
while (@positions > 0) { |
554
|
12
|
100
|
|
|
|
20
|
unless ($intersect) { |
555
|
4
|
|
|
|
|
7
|
$intersect = shift(@positions); |
556
|
4
|
|
|
|
|
9
|
($i_start, $i_end) = $self->_pre_rangei($intersect, $rel); |
557
|
4
|
|
|
|
|
11
|
my $map = $intersect->map; |
558
|
4
|
|
|
|
|
15
|
$known_maps{$map->unique_id} = $map; |
559
|
|
|
|
|
|
|
} |
560
|
|
|
|
|
|
|
|
561
|
12
|
|
|
|
|
15
|
my $compare = shift(@positions); |
562
|
12
|
|
|
|
|
22
|
($c_start, $c_end) = $self->_pre_rangei($compare, $rel); |
563
|
12
|
50
|
|
|
|
30
|
return unless $compare->_testStrand($intersect, $so); |
564
|
12
|
50
|
|
|
|
26
|
if ($compare->isa('Bio::Map::PositionI')) { |
565
|
12
|
|
|
|
|
15
|
my $this_map = $compare->map; |
566
|
12
|
50
|
|
|
|
21
|
if ($this_map) { |
567
|
12
|
|
|
|
|
23
|
$known_maps{$this_map->unique_id} = $this_map; |
568
|
|
|
|
|
|
|
} |
569
|
|
|
|
|
|
|
} |
570
|
|
|
|
|
|
|
else { |
571
|
0
|
|
|
|
|
0
|
$self->throw("Only Bio::Map::PositionI objects are supported, not [$compare]"); |
572
|
|
|
|
|
|
|
} |
573
|
|
|
|
|
|
|
|
574
|
12
|
|
|
|
|
35
|
my @starts = sort {$a <=> $b} ($i_start, $c_start); |
|
12
|
|
|
|
|
24
|
|
575
|
12
|
|
|
|
|
16
|
my @ends = sort {$a <=> $b} ($i_end, $c_end); |
|
12
|
|
|
|
|
19
|
|
576
|
|
|
|
|
|
|
|
577
|
12
|
|
|
|
|
13
|
my $start = pop @starts; # larger of the 2 starts |
578
|
12
|
|
|
|
|
11
|
my $end = shift @ends; # smaller of the 2 ends |
579
|
|
|
|
|
|
|
|
580
|
12
|
|
|
|
|
9
|
my $intersect_strand; # strand for the intersection |
581
|
12
|
50
|
33
|
|
|
31
|
if (defined($intersect->strand) && defined($compare->strand) && $intersect->strand == $compare->strand) { |
|
|
|
33
|
|
|
|
|
582
|
12
|
|
|
|
|
17
|
$intersect_strand = $compare->strand; |
583
|
|
|
|
|
|
|
} |
584
|
|
|
|
|
|
|
else { |
585
|
0
|
|
|
|
|
0
|
$intersect_strand = 0; |
586
|
|
|
|
|
|
|
} |
587
|
|
|
|
|
|
|
|
588
|
12
|
50
|
|
|
|
20
|
if ($start > $end) { |
589
|
0
|
|
|
|
|
0
|
return; |
590
|
|
|
|
|
|
|
} |
591
|
|
|
|
|
|
|
else { |
592
|
12
|
|
|
|
|
40
|
$intersect = $self->new(-start => $start, |
593
|
|
|
|
|
|
|
-end => $end, |
594
|
|
|
|
|
|
|
-strand => $intersect_strand); |
595
|
|
|
|
|
|
|
} |
596
|
|
|
|
|
|
|
} |
597
|
|
|
|
|
|
|
|
598
|
4
|
50
|
|
|
|
10
|
$intersect || return; |
599
|
4
|
|
|
|
|
9
|
my ($start, $end, $strand) = ($intersect->start, $intersect->end, $intersect->strand); |
600
|
|
|
|
|
|
|
|
601
|
4
|
|
|
|
|
6
|
my @intersects; |
602
|
4
|
|
|
|
|
13
|
foreach my $known_map (values %known_maps) { |
603
|
9
|
|
|
|
|
31
|
my $new_intersect = $intersect->new(-start => $start, |
604
|
|
|
|
|
|
|
-end => $end, |
605
|
|
|
|
|
|
|
-strand => $strand, |
606
|
|
|
|
|
|
|
-map => $known_map); |
607
|
9
|
100
|
|
|
|
24
|
$new_intersect->relative($rel) if $rel; |
608
|
9
|
|
|
|
|
16
|
push(@intersects, $new_intersect); |
609
|
|
|
|
|
|
|
} |
610
|
4
|
50
|
|
|
|
9
|
unless (@intersects) { |
611
|
0
|
0
|
|
|
|
0
|
$intersect->relative($rel) if $rel; |
612
|
0
|
|
|
|
|
0
|
@intersects = ($intersect); |
613
|
|
|
|
|
|
|
} |
614
|
|
|
|
|
|
|
|
615
|
4
|
|
|
|
|
17
|
my $result = Bio::Map::Mappable->new(); |
616
|
4
|
|
|
|
|
20
|
$result->add_position(@intersects); # sneaky, add_position can take a list of positions |
617
|
4
|
|
|
|
|
22
|
return $result; |
618
|
|
|
|
|
|
|
} |
619
|
|
|
|
|
|
|
|
620
|
|
|
|
|
|
|
=head2 union |
621
|
|
|
|
|
|
|
|
622
|
|
|
|
|
|
|
Title : union |
623
|
|
|
|
|
|
|
Usage : ($start, $stop, $strand) = $p1->union($p2); |
624
|
|
|
|
|
|
|
($start, $stop, $strand) = Bio::Map::Position->union(@positions); |
625
|
|
|
|
|
|
|
my $mappable = $p1->union($p2); |
626
|
|
|
|
|
|
|
my $mappable = Bio::Map::Position->union(@positions); |
627
|
|
|
|
|
|
|
Function: finds the minimal position/range that contains all of the positions |
628
|
|
|
|
|
|
|
Returns : Bio::Map::Mappable object who's positions are the |
629
|
|
|
|
|
|
|
cross-map-calculated union of the input positions on all the maps |
630
|
|
|
|
|
|
|
that the input positions belong to, OR, in list context, a three |
631
|
|
|
|
|
|
|
element array (start, end, strand) |
632
|
|
|
|
|
|
|
Args : a Bio::Map::PositionI to compare this one to, or a list of such |
633
|
|
|
|
|
|
|
OR |
634
|
|
|
|
|
|
|
a single Bio::Map::PositionI or array ref of such AND a |
635
|
|
|
|
|
|
|
Bio::Map::RelativeI to ask for the Position's union in terms of their |
636
|
|
|
|
|
|
|
relative position to the thing described by that Relative |
637
|
|
|
|
|
|
|
|
638
|
|
|
|
|
|
|
=cut |
639
|
|
|
|
|
|
|
|
640
|
|
|
|
|
|
|
sub union { |
641
|
|
|
|
|
|
|
# overriding the RangeI implementation so we can transfer map and handle |
642
|
|
|
|
|
|
|
# Relative |
643
|
38
|
|
|
38
|
1
|
57
|
my ($self, @args) = @_; |
644
|
38
|
50
|
|
|
|
62
|
$self->throw("Not enough arguments") unless @args >= 1; |
645
|
|
|
|
|
|
|
|
646
|
38
|
|
|
|
|
40
|
my @positions; |
647
|
|
|
|
|
|
|
my $rel; |
648
|
38
|
50
|
|
|
|
69
|
if ($self eq "Bio::Map::PositionI") { |
649
|
0
|
|
|
|
|
0
|
$self = "Bio::Map::Position"; |
650
|
0
|
|
|
|
|
0
|
$self->warn("calling static methods of an interface is deprecated; use $self instead"); |
651
|
|
|
|
|
|
|
} |
652
|
38
|
50
|
|
|
|
63
|
if (ref $self) { |
653
|
38
|
|
|
|
|
41
|
push(@positions, $self); |
654
|
|
|
|
|
|
|
} |
655
|
38
|
100
|
|
|
|
60
|
if (ref $args[0] eq 'ARRAY') { |
656
|
1
|
|
|
|
|
2
|
push(@positions, @{shift(@args)}); |
|
1
|
|
|
|
|
1
|
|
657
|
|
|
|
|
|
|
} |
658
|
|
|
|
|
|
|
else { |
659
|
37
|
|
|
|
|
41
|
push(@positions, shift(@args)); |
660
|
|
|
|
|
|
|
} |
661
|
38
|
100
|
66
|
|
|
156
|
if ($args[0] && $args[0]->isa('Bio::Map::RelativeI')) { |
662
|
37
|
|
|
|
|
36
|
$rel = shift(@args); |
663
|
|
|
|
|
|
|
} |
664
|
38
|
|
|
|
|
64
|
foreach my $arg (@args) { |
665
|
|
|
|
|
|
|
# avoid pushing undefined values into @positions |
666
|
0
|
0
|
|
|
|
0
|
push(@positions, $arg) if $arg; |
667
|
|
|
|
|
|
|
} |
668
|
38
|
50
|
|
|
|
61
|
$self->throw("Need at least 2 Positions") unless @positions >= 2; |
669
|
|
|
|
|
|
|
|
670
|
38
|
|
|
|
|
24
|
my (@starts, @ends, %known_maps, $union_strand); |
671
|
38
|
|
|
|
|
36
|
foreach my $compare (@positions) { |
672
|
|
|
|
|
|
|
# RangeI union allows start or end to be undefined; however _pre_rangei |
673
|
|
|
|
|
|
|
# will throw |
674
|
78
|
|
|
|
|
95
|
my ($start, $end) = $self->_pre_rangei($compare, $rel); |
675
|
|
|
|
|
|
|
|
676
|
78
|
50
|
|
|
|
167
|
if ($compare->isa('Bio::Map::PositionI')) { |
677
|
78
|
|
|
|
|
93
|
my $this_map = $compare->map; |
678
|
78
|
50
|
|
|
|
126
|
if ($this_map) { |
679
|
78
|
|
|
|
|
123
|
$known_maps{$this_map->unique_id} = $this_map; |
680
|
|
|
|
|
|
|
} |
681
|
|
|
|
|
|
|
} |
682
|
|
|
|
|
|
|
else { |
683
|
0
|
|
|
|
|
0
|
$self->throw("Only Bio::Map::PositionI objects are supported, not [$compare]"); |
684
|
|
|
|
|
|
|
} |
685
|
|
|
|
|
|
|
|
686
|
78
|
100
|
|
|
|
109
|
if (! defined $union_strand) { |
687
|
38
|
|
|
|
|
55
|
$union_strand = $compare->strand; |
688
|
|
|
|
|
|
|
} |
689
|
|
|
|
|
|
|
else { |
690
|
40
|
50
|
33
|
|
|
52
|
if (! defined $compare->strand or $union_strand ne $compare->strand) { |
691
|
0
|
|
|
|
|
0
|
$union_strand = 0; |
692
|
|
|
|
|
|
|
} |
693
|
|
|
|
|
|
|
} |
694
|
|
|
|
|
|
|
|
695
|
78
|
|
|
|
|
84
|
push(@starts, $start); |
696
|
78
|
|
|
|
|
92
|
push(@ends, $end); |
697
|
|
|
|
|
|
|
} |
698
|
|
|
|
|
|
|
|
699
|
38
|
|
|
|
|
91
|
@starts = sort { $a <=> $b } @starts; |
|
41
|
|
|
|
|
58
|
|
700
|
38
|
|
|
|
|
31
|
@ends = sort { $a <=> $b } @ends; |
|
41
|
|
|
|
|
35
|
|
701
|
38
|
|
|
|
|
31
|
my $start = shift @starts; |
702
|
38
|
|
|
|
|
32
|
my $end = pop @ends; |
703
|
|
|
|
|
|
|
|
704
|
38
|
|
|
|
|
31
|
my @unions; |
705
|
38
|
|
|
|
|
53
|
foreach my $known_map (values %known_maps) { |
706
|
45
|
|
|
|
|
135
|
my $new_union = $self->new(-start => $start, |
707
|
|
|
|
|
|
|
-end => $end, |
708
|
|
|
|
|
|
|
-strand => $union_strand, |
709
|
|
|
|
|
|
|
-map => $known_map); |
710
|
45
|
100
|
|
|
|
110
|
$new_union->relative($rel) if $rel; |
711
|
45
|
|
|
|
|
66
|
push(@unions, $new_union); |
712
|
|
|
|
|
|
|
} |
713
|
38
|
50
|
|
|
|
56
|
unless (@unions) { |
714
|
0
|
|
|
|
|
0
|
@unions = ($self->new(-start => $start, |
715
|
|
|
|
|
|
|
-end => $end, |
716
|
|
|
|
|
|
|
-strand => $union_strand)); |
717
|
0
|
0
|
|
|
|
0
|
$unions[0]->relative($rel) if $rel; |
718
|
|
|
|
|
|
|
} |
719
|
|
|
|
|
|
|
|
720
|
38
|
|
|
|
|
78
|
my $result = Bio::Map::Mappable->new(); |
721
|
38
|
|
|
|
|
68
|
$result->add_position(@unions); # sneaky, add_position can take a list of positions |
722
|
38
|
|
|
|
|
102
|
return $result; |
723
|
|
|
|
|
|
|
} |
724
|
|
|
|
|
|
|
|
725
|
|
|
|
|
|
|
=head2 overlap_extent |
726
|
|
|
|
|
|
|
|
727
|
|
|
|
|
|
|
Title : overlap_extent |
728
|
|
|
|
|
|
|
Usage : ($a_unique,$common,$b_unique) = $a->overlap_extent($b) |
729
|
|
|
|
|
|
|
Function: Provides actual amount of overlap between two different |
730
|
|
|
|
|
|
|
positions |
731
|
|
|
|
|
|
|
Example : |
732
|
|
|
|
|
|
|
Returns : array of values containing the length unique to the calling |
733
|
|
|
|
|
|
|
position, the length common to both, and the length unique to |
734
|
|
|
|
|
|
|
the argument position |
735
|
|
|
|
|
|
|
Args : a position |
736
|
|
|
|
|
|
|
|
737
|
|
|
|
|
|
|
=cut |
738
|
|
|
|
|
|
|
|
739
|
|
|
|
|
|
|
#*** should this be overridden from RangeI? |
740
|
|
|
|
|
|
|
|
741
|
|
|
|
|
|
|
=head2 disconnected_ranges |
742
|
|
|
|
|
|
|
|
743
|
|
|
|
|
|
|
Title : disconnected_ranges |
744
|
|
|
|
|
|
|
Usage : my @disc_ranges = Bio::Map::Position->disconnected_ranges(@ranges); |
745
|
|
|
|
|
|
|
Function: Creates the minimal set of positions such that each input position is |
746
|
|
|
|
|
|
|
fully contained by at least one output position, and none of the |
747
|
|
|
|
|
|
|
output positions overlap. |
748
|
|
|
|
|
|
|
Returns : Bio::Map::Mappable with the calculated disconnected ranges |
749
|
|
|
|
|
|
|
Args : a Bio::Map::PositionI to compare this one to, or a list of such, |
750
|
|
|
|
|
|
|
OR |
751
|
|
|
|
|
|
|
a single Bio::Map::PositionI or array ref of such AND a |
752
|
|
|
|
|
|
|
Bio::Map::RelativeI to consider all Position's co-ordinates in terms |
753
|
|
|
|
|
|
|
of their relative position to the thing described by that Relative, |
754
|
|
|
|
|
|
|
AND, optionally, an int for the minimum percentage of overlap that |
755
|
|
|
|
|
|
|
must be present before considering two ranges to be overlapping |
756
|
|
|
|
|
|
|
(default 0) |
757
|
|
|
|
|
|
|
|
758
|
|
|
|
|
|
|
=cut |
759
|
|
|
|
|
|
|
|
760
|
|
|
|
|
|
|
sub disconnected_ranges { |
761
|
|
|
|
|
|
|
# overriding the RangeI implementation so we can transfer map and handle |
762
|
|
|
|
|
|
|
# Relative |
763
|
10
|
|
|
10
|
1
|
12
|
my ($self, @args) = @_; |
764
|
10
|
50
|
|
|
|
18
|
$self->throw("Not enough arguments") unless @args >= 1; |
765
|
|
|
|
|
|
|
|
766
|
10
|
|
|
|
|
9
|
my @positions; |
767
|
|
|
|
|
|
|
my $rel; |
768
|
10
|
|
|
|
|
12
|
my $overlap = 0; |
769
|
10
|
50
|
|
|
|
24
|
if ($self eq "Bio::Map::PositionI") { |
770
|
0
|
|
|
|
|
0
|
$self = "Bio::Map::Position"; |
771
|
0
|
|
|
|
|
0
|
$self->warn("calling static methods of an interface is deprecated; use $self instead"); |
772
|
|
|
|
|
|
|
} |
773
|
10
|
50
|
|
|
|
21
|
if (ref $self) { |
774
|
10
|
|
|
|
|
10
|
push(@positions, $self); |
775
|
|
|
|
|
|
|
} |
776
|
10
|
50
|
|
|
|
22
|
if (ref $args[0] eq 'ARRAY') { |
777
|
10
|
|
|
|
|
10
|
push(@positions, @{shift(@args)}); |
|
10
|
|
|
|
|
18
|
|
778
|
|
|
|
|
|
|
} |
779
|
|
|
|
|
|
|
else { |
780
|
0
|
|
|
|
|
0
|
push(@positions, shift(@args)); |
781
|
|
|
|
|
|
|
} |
782
|
10
|
50
|
33
|
|
|
54
|
if ($args[0] && $args[0]->isa('Bio::Map::RelativeI')) { |
783
|
10
|
|
|
|
|
9
|
$rel = shift(@args); |
784
|
10
|
|
|
|
|
11
|
$overlap = shift(@args); |
785
|
|
|
|
|
|
|
} |
786
|
10
|
|
|
|
|
18
|
foreach my $arg (@args) { |
787
|
0
|
0
|
|
|
|
0
|
push(@positions, $arg) if $arg; |
788
|
|
|
|
|
|
|
} |
789
|
10
|
50
|
|
|
|
17
|
$self->throw("Need at least 2 Positions") unless @positions >= 2; |
790
|
|
|
|
|
|
|
|
791
|
10
|
|
|
|
|
9
|
my %known_maps; |
792
|
10
|
|
|
|
|
15
|
foreach my $pos (@positions) { |
793
|
55
|
50
|
|
|
|
98
|
$pos->isa('Bio::Map::PositionI') || $self->throw("Must supply only Bio::Map::PositionI objects, not [$pos]"); |
794
|
55
|
|
50
|
|
|
56
|
my $map = $pos->map || next; |
795
|
55
|
|
|
|
|
82
|
$known_maps{$map->unique_id} = $map; |
796
|
|
|
|
|
|
|
} |
797
|
10
|
|
|
|
|
9
|
my %prior_positions; |
798
|
10
|
|
|
|
|
16
|
foreach my $map (values %known_maps) { |
799
|
15
|
|
|
|
|
40
|
foreach my $pos ($map->get_positions) { |
800
|
92
|
|
|
|
|
127
|
$prior_positions{$pos} = 1; |
801
|
|
|
|
|
|
|
} |
802
|
|
|
|
|
|
|
} |
803
|
|
|
|
|
|
|
|
804
|
10
|
|
|
|
|
15
|
my @outranges = (); |
805
|
10
|
|
|
|
|
14
|
foreach my $inrange (@positions) { |
806
|
55
|
|
|
|
|
49
|
my @outranges_new = (); |
807
|
55
|
|
|
|
|
53
|
my %overlapping_ranges = (); |
808
|
|
|
|
|
|
|
|
809
|
55
|
|
|
|
|
97
|
for (my $i=0; $i<@outranges; $i++) { |
810
|
50
|
|
|
|
|
48
|
my $outrange = $outranges[$i]; |
811
|
50
|
100
|
|
|
|
102
|
if ($inrange->overlaps($outrange, undef, $rel, $overlap)) { |
812
|
35
|
|
|
|
|
61
|
my $union_able = $inrange->union($outrange, $rel); # using $inrange->union($outrange, $rel); gives >6x speedup, |
813
|
|
|
|
|
|
|
# but different answer, not necessarily incorrect... |
814
|
35
|
|
|
|
|
65
|
foreach my $pos ($union_able->get_positions) { |
815
|
35
|
|
|
|
|
62
|
$overlapping_ranges{$pos->toString} = $pos; # we flatten down to a result on a single map |
816
|
|
|
|
|
|
|
# to avoid creating 10s of thousands of positions during this process; |
817
|
|
|
|
|
|
|
# we then apply the final answer to all maps at the very end |
818
|
35
|
|
|
|
|
107
|
last; |
819
|
|
|
|
|
|
|
} |
820
|
|
|
|
|
|
|
} |
821
|
|
|
|
|
|
|
else { |
822
|
15
|
|
|
|
|
42
|
push(@outranges_new, $outrange); |
823
|
|
|
|
|
|
|
} |
824
|
|
|
|
|
|
|
} |
825
|
|
|
|
|
|
|
|
826
|
55
|
|
|
|
|
68
|
@outranges = @outranges_new; |
827
|
|
|
|
|
|
|
|
828
|
55
|
|
|
|
|
67
|
my @overlappers = values %overlapping_ranges; |
829
|
55
|
100
|
|
|
|
68
|
if (@overlappers) { |
830
|
35
|
50
|
|
|
|
42
|
if (@overlappers > 1) { |
831
|
0
|
|
|
|
|
0
|
my $merged_range_able = shift(@overlappers)->union(\@overlappers, $rel); |
832
|
0
|
|
|
|
|
0
|
push(@outranges, $merged_range_able->get_positions); |
833
|
|
|
|
|
|
|
} |
834
|
|
|
|
|
|
|
else { |
835
|
35
|
|
|
|
|
74
|
push(@outranges, @overlappers); |
836
|
|
|
|
|
|
|
} |
837
|
|
|
|
|
|
|
} |
838
|
|
|
|
|
|
|
else { |
839
|
20
|
|
|
|
|
47
|
push(@outranges, $self->new(-start => $inrange->start($rel), -end => $inrange->end($rel), -strand => $inrange->strand, -map => $inrange->map, -relative => $rel)); |
840
|
|
|
|
|
|
|
} |
841
|
|
|
|
|
|
|
} |
842
|
|
|
|
|
|
|
|
843
|
|
|
|
|
|
|
# purge positions that were created whilst calculating the answer, but |
844
|
|
|
|
|
|
|
# aren't the final answer and weren't there previously |
845
|
10
|
|
|
|
|
15
|
my %answers = map { $_ => 1 } @outranges; |
|
20
|
|
|
|
|
48
|
|
846
|
10
|
|
|
|
|
23
|
foreach my $map (values %known_maps) { |
847
|
15
|
|
|
|
|
31
|
foreach my $pos ($map->get_positions) { |
848
|
154
|
100
|
66
|
|
|
322
|
if (! exists $prior_positions{$pos} && ! exists $answers{$pos}) { |
849
|
42
|
|
|
|
|
86
|
$map->purge_positions($pos); |
850
|
|
|
|
|
|
|
} |
851
|
|
|
|
|
|
|
} |
852
|
|
|
|
|
|
|
} |
853
|
|
|
|
|
|
|
|
854
|
10
|
|
|
|
|
12
|
my %post_positions; |
855
|
10
|
|
|
|
|
19
|
foreach my $map (values %known_maps) { |
856
|
15
|
|
|
|
|
27
|
foreach my $pos ($map->get_positions) { |
857
|
112
|
|
|
|
|
146
|
$post_positions{$pos} = 1; |
858
|
|
|
|
|
|
|
} |
859
|
|
|
|
|
|
|
} |
860
|
|
|
|
|
|
|
|
861
|
10
|
50
|
|
|
|
22
|
@outranges || return; |
862
|
|
|
|
|
|
|
|
863
|
|
|
|
|
|
|
# make an outrange on all known maps |
864
|
10
|
|
|
|
|
12
|
my @final_positions; |
865
|
10
|
|
|
|
|
22
|
foreach my $map (values %known_maps) { |
866
|
15
|
|
|
|
|
20
|
foreach my $pos (@outranges) { |
867
|
30
|
100
|
|
|
|
45
|
if ($pos->map eq $map) { |
868
|
20
|
|
|
|
|
34
|
push(@final_positions, $pos); |
869
|
|
|
|
|
|
|
} |
870
|
|
|
|
|
|
|
else { |
871
|
10
|
|
|
|
|
22
|
push(@final_positions, $pos->new(-start => $pos->start, |
872
|
|
|
|
|
|
|
-end => $pos->end, |
873
|
|
|
|
|
|
|
-relative => $pos->relative, |
874
|
|
|
|
|
|
|
-map => $map)); |
875
|
|
|
|
|
|
|
} |
876
|
|
|
|
|
|
|
} |
877
|
|
|
|
|
|
|
} |
878
|
|
|
|
|
|
|
|
879
|
|
|
|
|
|
|
# assign the positions to a result mappable |
880
|
10
|
|
|
|
|
27
|
my $result = Bio::Map::Mappable->new(); |
881
|
10
|
|
|
|
|
21
|
$result->add_position(@final_positions); # sneaky, add_position can take a list of positions |
882
|
10
|
|
|
|
|
66
|
return $result; |
883
|
|
|
|
|
|
|
} |
884
|
|
|
|
|
|
|
|
885
|
|
|
|
|
|
|
# get start & end suitable for rangeI methods, taking relative into account |
886
|
|
|
|
|
|
|
sub _pre_rangei { |
887
|
490
|
|
|
490
|
|
514
|
my ($self, $other, $rel) = @_; |
888
|
490
|
50
|
|
|
|
648
|
$self->throw("Must supply an object") unless $other; |
889
|
490
|
100
|
|
|
|
740
|
if ($rel) { |
890
|
414
|
50
|
|
|
|
555
|
$self->throw("Must supply an object for the Relative argument") unless ref($rel); |
891
|
414
|
50
|
|
|
|
854
|
$self->throw("This is [$rel], not a Bio::Map::RelativeI") unless $rel->isa('Bio::Map::RelativeI'); |
892
|
|
|
|
|
|
|
} |
893
|
|
|
|
|
|
|
|
894
|
490
|
|
|
|
|
338
|
my ($other_start, $other_end); |
895
|
490
|
100
|
|
|
|
585
|
if (ref($other)) { |
896
|
489
|
50
|
|
|
|
651
|
if (ref($other) eq 'ARRAY') { |
897
|
0
|
|
|
|
|
0
|
$self->throw("_pre_rangei got an array"); |
898
|
|
|
|
|
|
|
} |
899
|
489
|
50
|
33
|
|
|
1632
|
$self->throw("This is [$other], not a Bio::RangeI object") unless defined $other && $other->isa('Bio::RangeI'); |
900
|
|
|
|
|
|
|
|
901
|
489
|
100
|
|
|
|
752
|
if ($other->isa('Bio::Map::PositionI')) { |
902
|
|
|
|
|
|
|
# to get the desired start/end we need the position to be on a map; |
903
|
|
|
|
|
|
|
# if it isn't on one temporarily place it on self's map |
904
|
|
|
|
|
|
|
# - this lets us have 'generic' positions that aren't on any map |
905
|
|
|
|
|
|
|
# but have a relative defined and can thus be usefully compared to |
906
|
|
|
|
|
|
|
# positions that /are/ on maps |
907
|
488
|
|
|
|
|
584
|
my $other_map = $other->map; |
908
|
488
|
50
|
|
|
|
798
|
unless ($other_map) { |
909
|
0
|
|
0
|
|
|
0
|
my $self_map = $self->map || $self->throw("Trying to compare two positions but neither had been placed on a map"); |
910
|
0
|
|
|
|
|
0
|
$other->map($self_map); |
911
|
|
|
|
|
|
|
} |
912
|
|
|
|
|
|
|
|
913
|
|
|
|
|
|
|
# want start and end positions relative to the supplied rel or map start |
914
|
488
|
|
66
|
|
|
726
|
$rel ||= $other->absolute_relative; |
915
|
488
|
|
|
|
|
760
|
$other_start = $other->start($rel); |
916
|
488
|
|
|
|
|
741
|
$other_end = $other->end($rel); |
917
|
|
|
|
|
|
|
|
918
|
488
|
50
|
|
|
|
789
|
unless ($other_map) { |
919
|
0
|
|
|
|
|
0
|
$self->map->purge_positions($other); |
920
|
|
|
|
|
|
|
} |
921
|
|
|
|
|
|
|
} |
922
|
|
|
|
|
|
|
else { |
923
|
1
|
|
|
|
|
5
|
$other_start = $other->start; |
924
|
1
|
|
|
|
|
4
|
$other_end = $other->end; |
925
|
|
|
|
|
|
|
} |
926
|
|
|
|
|
|
|
} |
927
|
|
|
|
|
|
|
else { |
928
|
1
|
50
|
|
|
|
5
|
$self->throw("not a number") unless looks_like_number($other); |
929
|
1
|
|
|
|
|
2
|
$other_start = $other_end = $other; |
930
|
|
|
|
|
|
|
} |
931
|
|
|
|
|
|
|
|
932
|
490
|
50
|
|
|
|
555
|
$other->throw("start is undefined") unless defined $other_start; |
933
|
490
|
50
|
|
|
|
507
|
$other->throw("end is undefined") unless defined $other_end; |
934
|
|
|
|
|
|
|
|
935
|
490
|
|
|
|
|
608
|
return ($other_start, $other_end); |
936
|
|
|
|
|
|
|
} |
937
|
|
|
|
|
|
|
|
938
|
|
|
|
|
|
|
1; |