line |
stmt |
bran |
cond |
sub |
pod |
time |
code |
1
|
|
|
|
|
|
|
package Bio::Protease::Role::WithCache; |
2
|
|
|
|
|
|
|
{ |
3
|
|
|
|
|
|
|
$Bio::Protease::Role::WithCache::VERSION = '1.112900'; # TRIAL |
4
|
|
|
|
|
|
|
} |
5
|
|
|
|
|
|
|
|
6
|
|
|
|
|
|
|
# ABSTRACT: A role that adds optional memoization of ProteaseI methods |
7
|
|
|
|
|
|
|
|
8
|
4
|
|
|
4
|
|
1630
|
use Moose::Role; |
|
4
|
|
|
|
|
4
|
|
|
4
|
|
|
|
|
17
|
|
9
|
4
|
|
|
4
|
|
12789
|
use MooseX::Types::Moose 'Bool'; |
|
4
|
|
|
|
|
7
|
|
|
4
|
|
|
|
|
24
|
|
10
|
4
|
|
|
4
|
|
12722
|
use namespace::autoclean; |
|
4
|
|
|
|
|
5
|
|
|
4
|
|
|
|
|
26
|
|
11
|
|
|
|
|
|
|
|
12
|
|
|
|
|
|
|
has use_cache => ( is => 'ro', isa => Bool, default => 0 ); |
13
|
|
|
|
|
|
|
|
14
|
|
|
|
|
|
|
has cache => ( |
15
|
|
|
|
|
|
|
is => 'ro', |
16
|
|
|
|
|
|
|
lazy => 1, |
17
|
|
|
|
|
|
|
does => 'Cache::Ref::Role::API', |
18
|
|
|
|
|
|
|
predicate => '_has_cache', |
19
|
|
|
|
|
|
|
default => |
20
|
|
|
|
|
|
|
sub { require Cache::Ref::LRU; Cache::Ref::LRU->new( size => 5000 ) }, |
21
|
|
|
|
|
|
|
); |
22
|
|
|
|
|
|
|
|
23
|
|
|
|
|
|
|
foreach my $method (qw(digest is_substrate cleavage_sites)) { |
24
|
|
|
|
|
|
|
around $method => sub { |
25
|
|
|
|
|
|
|
my ($orig, $self, $substrate) = @_; |
26
|
|
|
|
|
|
|
|
27
|
|
|
|
|
|
|
return $self->$orig($substrate) if ( !$self->use_cache or !$substrate ); |
28
|
|
|
|
|
|
|
|
29
|
|
|
|
|
|
|
my $computed = $self->cache->get("$method-$substrate"); |
30
|
|
|
|
|
|
|
|
31
|
|
|
|
|
|
|
if ($computed) { |
32
|
|
|
|
|
|
|
return @$computed; |
33
|
|
|
|
|
|
|
} |
34
|
|
|
|
|
|
|
else { |
35
|
|
|
|
|
|
|
my @result = $self->$orig($substrate); |
36
|
|
|
|
|
|
|
$self->cache->set( "$method-$substrate" => \@result ); |
37
|
|
|
|
|
|
|
return @result; |
38
|
|
|
|
|
|
|
} |
39
|
|
|
|
|
|
|
}; |
40
|
|
|
|
|
|
|
} |
41
|
|
|
|
|
|
|
|
42
|
|
|
|
|
|
|
|
43
|
|
|
|
|
|
|
1; |
44
|
|
|
|
|
|
|
|
45
|
|
|
|
|
|
|
__END__ |
46
|
|
|
|
|
|
|
=pod |
47
|
|
|
|
|
|
|
|
48
|
|
|
|
|
|
|
=head1 NAME |
49
|
|
|
|
|
|
|
|
50
|
|
|
|
|
|
|
Bio::Protease::Role::WithCache - A role that adds optional memoization of ProteaseI methods |
51
|
|
|
|
|
|
|
|
52
|
|
|
|
|
|
|
=head1 VERSION |
53
|
|
|
|
|
|
|
|
54
|
|
|
|
|
|
|
version 1.112900 |
55
|
|
|
|
|
|
|
|
56
|
|
|
|
|
|
|
=head1 SYNOPSIS |
57
|
|
|
|
|
|
|
|
58
|
|
|
|
|
|
|
package My::Protease; |
59
|
|
|
|
|
|
|
use Moose; |
60
|
|
|
|
|
|
|
with qw(Bio::ProteaseI Bio::Protease::Role::WithCache); |
61
|
|
|
|
|
|
|
|
62
|
|
|
|
|
|
|
sub _cuts { ... } |
63
|
|
|
|
|
|
|
|
64
|
|
|
|
|
|
|
# Done, all ProteaseI methods now support optional caching |
65
|
|
|
|
|
|
|
# through the 'has_cache' and 'cache' attributes |
66
|
|
|
|
|
|
|
|
67
|
|
|
|
|
|
|
1; |
68
|
|
|
|
|
|
|
|
69
|
|
|
|
|
|
|
=head1 ATTRIBUTES |
70
|
|
|
|
|
|
|
|
71
|
|
|
|
|
|
|
=head2 use_cache |
72
|
|
|
|
|
|
|
|
73
|
|
|
|
|
|
|
Turn caching on, trading memory for speed. Defaults to 0 (no caching). |
74
|
|
|
|
|
|
|
Useful when any method is being called several times with the same |
75
|
|
|
|
|
|
|
argument. |
76
|
|
|
|
|
|
|
|
77
|
|
|
|
|
|
|
my $p = Bio::Protease->new( specificity => 'trypsin', use_cache => 0 ); |
78
|
|
|
|
|
|
|
my $c = Bio::Protease->new( specificity => 'trypsin', use_cache => 1 ); |
79
|
|
|
|
|
|
|
|
80
|
|
|
|
|
|
|
my $substrate = 'MAAEELRKVIKPR' x 10; |
81
|
|
|
|
|
|
|
|
82
|
|
|
|
|
|
|
$p->digest( $substrate ) for (1..1000); # time: 5.11s |
83
|
|
|
|
|
|
|
$c->digest( $substrate ) for (1..1000); # time: 0.12s |
84
|
|
|
|
|
|
|
|
85
|
|
|
|
|
|
|
=head2 cache |
86
|
|
|
|
|
|
|
|
87
|
|
|
|
|
|
|
The cache object, which has to do the L<Cache::Ref::Role::API> role. |
88
|
|
|
|
|
|
|
Uses L<Cache::Ref::LRU> by default with a cache size of 5000, but you |
89
|
|
|
|
|
|
|
can set this to your liking at construction time: |
90
|
|
|
|
|
|
|
|
91
|
|
|
|
|
|
|
my $p = Bio::Protease->new( |
92
|
|
|
|
|
|
|
use_cache => 1, |
93
|
|
|
|
|
|
|
cache => Cache::Ref::Random->new( size => 50 ), |
94
|
|
|
|
|
|
|
specificity => 'trypsin' |
95
|
|
|
|
|
|
|
); |
96
|
|
|
|
|
|
|
|
97
|
|
|
|
|
|
|
=head1 AUTHOR |
98
|
|
|
|
|
|
|
|
99
|
|
|
|
|
|
|
Bruno Vecchi <vecchi.b gmail.com> |
100
|
|
|
|
|
|
|
|
101
|
|
|
|
|
|
|
=head1 COPYRIGHT AND LICENSE |
102
|
|
|
|
|
|
|
|
103
|
|
|
|
|
|
|
This software is copyright (c) 2011 by Bruno Vecchi. |
104
|
|
|
|
|
|
|
|
105
|
|
|
|
|
|
|
This is free software; you can redistribute it and/or modify it under |
106
|
|
|
|
|
|
|
the same terms as the Perl 5 programming language system itself. |
107
|
|
|
|
|
|
|
|
108
|
|
|
|
|
|
|
=cut |
109
|
|
|
|
|
|
|
|